Transient Receptor Potential Canonical Type 3 Channels-Their Evolving Role in Hypertension and Its Related Complications

被引：15

作者：

Wang, Peijian ^{[1
]}

Liu, Daoyan ^{[1
]}

Tepel, Martin ^{[2
]}

Zhu, Zhiming ^{[1
]}

机构：

[1] Third Mil Med Univ, Dept Hypertens & Endocrinol, Ctr Hypertens & Metab Dis, Daping Hosp,Chongqing Inst Hypertens, Chongqing 400042, Peoples R China

[2] Univ Southern Denmark, Inst Mol Med, Odense Univ Hosp, Dept Nephrol, Odense, Denmark

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2013年 / 61卷 / 06期

基金：

中国国家自然科学基金;

关键词：

transient receptor potential canonical type 3 channel; hypertension; calcium signaling; target organ damages; TRPC3; CHANNELS; OXIDATIVE STRESS; CATION CHANNELS; CALCIUM INFLUX; CA2+ ENTRY; EXPRESSION; ACTIVATION; HYPERTROPHY; CONTRIBUTES; ENDOTHELIUM;

D O I：

10.1097/FJC.0b013e31828748a1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies indicate that transient receptor potential canonical type 3 (TRPC3) channels contribute to the regulation of blood pressure and vascular and renal function. Several studies show that TRPC3 dysfunction is associated with hypertension, atherosclerosis, cardiac hypertrophy, and cerebrovascular events. In this review, we summarize the role of TRPC3 channels in the cardiovascular system, and we focus on their pathophysiogical role in hypertension and related target organ damages. We provide new insight into the involvement of TRPC3 channels in the development of hypertension and its related complications.

引用

页码：455 / 460

页数：6

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