Geminal bis(silane)-controlled regio- and stereoselective oxidative Heck reaction of enol ethers with terminal alkenes to give push-pull 1,3-dienes

被引：16
作者：
Li, Linjie [1 ]
Chu, Yang [1 ]
Gao, Lu [1 ]
Song, Zhenlei [1 ,2 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 85期
关键词：
H BOND ACTIVATION; CROSS-COUPLING REACTION; SELECTIVE ACCESS; C-C; FUNCTIONALIZATION; ACRYLATES; EFFICIENT; ARYL; OLEFINATION; REARRANGEMENT;
D O I：
10.1039/c5cc06448a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A geminal bis(silane)-controlled regio- and stereoselective oxidative Heck reaction of enol ethers with terminal alkenes has been developed. The reaction proceeds with alpha,beta-coupling regioselectivity to give push-pull Z,E-1,3-dienes in good yields. The product showed valuable utility in Sakurai homoallylation with acetals to generate alpha-substituted-gamma-keto esters with good anti-selectivity.
引用
收藏
页码：15546 / 15549
页数：4
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