HIV-1 Vpu - an ion channel in search of a job

被引：36
作者：
Strebel, Klaus [1 ]
机构：
[1] NIAID, Viral Biochem Sect, Mol Microbiol Lab, Bethesda, MD 20892 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2014年 / 1838卷 / 04期
基金：
美国国家卫生研究院;
关键词：
HIV-1; Vpu; BST-2; Tetherin; Ion channel; CD4; CHIMERIC ENVELOPE GLYCOPROTEINS; CLATHRIN-MEDIATED ENDOCYTOSIS; ANTI-TETHERIN ACTIVITIES; VIRAL PROTEIN-U; TYPE-1; VPU; TRANSMEMBRANE DOMAIN; CYTOPLASMIC DOMAIN; PARTICLE RELEASE; VIRUS RELEASE; CELL-SURFACE;
D O I：
10.1016/j.bbamem.2013.06.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vpu is a small membrane protein encoded by HIV-1 and some SIV isolates. The protein is best known for its ability to degrade CD4 and to enhance the release of progeny virions from infected cells. However, Vpu also promotes host-cell apoptosis by deregulating the NF kappa B signaling pathway and it assembles into cation-conducting membrane pores. This review summarizes our current understanding of these various functions of Vpu with particular emphasis on recent progress in the Vpu field. This article is part of a Special Issue entitled: Viral Membrane Proteins Channels for Cellular Networking. Published by Elsevier B.V.
引用
收藏
页码：1074 / 1081
页数：8
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