Stromal control of intestinal development and the stem cell niche

被引：23
|
作者：
Greicius, Gediminas [1 ]
Virshup, David M. [1 ,2 ]
机构：
[1] Duke NUS Med Sch, Program Canc & Stem Cell Biol, Singapore 169857, Singapore
[2] Duke Univ, Dept Pediat, Sch Med, Durham, NC 27703 USA
来源：
DIFFERENTIATION | 2019年 / 108卷
基金：
英国医学研究理事会;
关键词：
Intestinal stem cell; PdgfRa; FoxL1: Gli1; Wnt signaling; Stem cell niche; Intestinal stroma; Telocytes; Myofibroblast; PDGFR-ALPHA; LAMINA PROPRIA; SELF-RENEWAL; WNT; EXPRESSION; HEDGEHOG; MOUSE; DIFFERENTIATION; GROWTH; PROLIFERATION;
D O I：
10.1016/j.diff.2019.01.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Intestinal homeostasis is dependent on the continuous production of differentiated epithelial cells from a sustainable and resilient stem cell compartment. Wnt/beta-catenin signaling plays a central role in this process, cooperating with R-spondins, growth factors and regulators of the TGF-beta/BMP pathway to generate a specialized tissue microenvironment that regulates the intestinal stem cell niche. Recent studies revealed that many of these factors are produced in a paracrine manner by specialized cell populations that reside in the subepithelial stroma. These stromal signal-producing cells, variously called telocytes and myofibroblasts, can be identified by expression of specific genes including PdgfRa, Gli1 and FoxL1. In this review we discuss how the intestinal stem cell niche is established during development and then sustained during adult intestinal homeostasis by these stromal cell populations. The signaling stroma cells regulate intestinal stem cell development into different epithelial lineages and play an important role in the response to environmental stresses.
引用
收藏
页码：8 / 16
页数：9
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