Epigenetic targeting of cancer stem cells by polyphenols (cancer stem cells targeting)

被引:17
作者
Ghasemi, Sorayya [1 ,2 ]
Xu, Suowen [3 ]
Nabavi, Seyed Mohammad [4 ]
Amirkhani, Mohammad Amir [5 ]
Sureda, Antoni [6 ,7 ,8 ]
Tejada, Silvia [7 ,8 ,9 ]
Lorigooini, Zahra [10 ]
机构
[1] Shahrekord Univ Med Sci, Cellular & Mol Res Ctr, Basic Hlth Sci Inst, Shahrekord, Iran
[2] Shahrekord Univ Med Sci, Canc Res Ctr, Shahrekord, Iran
[3] Univ Rochester, Aab Cardiovasc Res Inst, Rochester, NY USA
[4] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran
[5] Univ Tehran Med Sci, Stem Cell & Regenerat Med Inst, Tehran, Iran
[6] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain
[7] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain
[8] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid, Spain
[9] Univ Balearic Isl, Biol Dept, Lab Neurophysiol, Palma De Mallorca, Spain
[10] Shahrekord Univ Med Sci, Med Plants Res Ctr, Basic Hlth Sci Inst, Shahrekord, Iran
关键词
cancer stem cells (CSCs); epigenetics; polyphenols; HISTONE DEACETYLASE INHIBITORS; GREEN TEA POLYPHENOL; LONG NONCODING RNAS; MAMMARY PROMOTER HYPERMETHYLATION; BIOACTIVE DIETARY-COMPONENTS; DNA METHYLATION INHIBITORS; PROSTATE-CANCER; BREAST-CANCER; LUNG-CANCER; EMERGING MECHANISMS;
D O I
10.1002/ptr.7059
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Epigenetic alterations are one of the main factors that disrupt the expression of genes and consequently, they have an important role in the carcinogenicity and the progression of different cancers. Cancer stem cells (CSCs) are accountable for the recurrence, metastasis, and therapeutic failure of cancer. The noticeable and specific pathways in CSCs can be organized by epigenetic mechanisms such as DNA methylation, chromatin remodeling, regulatory RNAs, among others. Since epigenetics modifications can be changed and reversed, it is a possible tool for cancer control and treatment. Epigenetic therapies against CSCs are emerging as a very new strategy with a good future expectation to treat cancer patients. Phenolic compounds are a vast group of substances with anticarcinogenic functions, antiinflammatory, and antioxidative activities. It seems these characteristics are related to neutralizing CSCs development, their microenvironment, and metabolism through epigenetic mechanisms. In the current work, the types of epigenetic changes known in these cells are introduced. In addition, some studies about the use of polyphenols acting through a variety of epigenetic mechanisms to counteract these cells will be reviewed. The reported results seem to indicate that the use of these phenolic compounds may be useful for CSCs defeat.
引用
收藏
页码:3649 / 3664
页数:16
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