Both expansion of regulatory GRI+ CD11b+ myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis

被引：63
作者：
Voisin, MB
Buzoni-Gatel, D
Bout, D
Velge-Roussel, F
机构：
[1] UMR Univ INRA, UFR Sci Pharmaceut, F-37200 Tours, France
[2] INRA, Inst Pasteur, Unite Reponse Precoce Parasites, Paris, France
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 09期
关键词：
D O I：
10.1128/IAI.72.9.5487-5492.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Oral infection with Toxoplasma gondii leads to transient systemic hyporesponsiveness. In this report, we characterized the presence in the lungs of GR1(+) CD11b(+) myeloid cells that have potent nitric oxide-dependent immunoregulatory properties. We also demonstrated the interleukin 2-reversible anergy of both pulmonary CD8(+) and CD4(+) activated T lymphocytes with infection.
引用
收藏
页码：5487 / 5492
页数：6
相关论文
共 33 条
[1]  
ABRAHAMSOHN IA, 1995, J IMMUNOL, V155, P3955
[2]   Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen [J].
Akbari, O ;
DeKruyff, RH ;
Umetsu, DT .
NATURE IMMUNOLOGY, 2001, 2 (08) :725-731
[3]   Infection of dendritic cells by murine cytomegalovirus induces functional paralysis [J].
Andrews, DM ;
Andoniou, CE ;
Granucci, F ;
Ricciardi-Castagnoli, P ;
Degli-Esposti, MA .
NATURE IMMUNOLOGY, 2001, 2 (11) :1077-1084
[4]   A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1+ macrophages that suppress naive CD4+ T cell proliferation via an IFN-γ and nitric oxide-dependent mechanism [J].
Atochina, O ;
Daly-Engel, T ;
Piskorska, D ;
McGuire, E ;
Harn, DA .
JOURNAL OF IMMUNOLOGY, 2001, 167 (08) :4293-4302
[5]   ROLES OF GAMMA-INTERFERON AND OTHER CYTOKINES IN SUPPRESSION OF THE SPLEEN-CELL PROLIFERATIVE RESPONSE TO CONCANAVALIN-A AND TOXOPLASMA ANTIGEN DURING ACUTE TOXOPLASMOSIS [J].
CANDOLFI, E ;
HUNTER, CA ;
REMINGTON, JS .
INFECTION AND IMMUNITY, 1995, 63 (03) :751-756
[6]   MITOGEN-SPECIFIC AND ANTIGEN-SPECIFIC PROLIFERATION OF T-CELLS IN MURINE TOXOPLASMOSIS IS INHIBITED BY REACTIVE NITROGEN INTERMEDIATES [J].
CANDOLFI, E ;
HUNTER, CA ;
REMINGTON, JS .
INFECTION AND IMMUNITY, 1994, 62 (05) :1995-2001
[7]   Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines:: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule [J].
Eisenstein, TK .
MICROBES AND INFECTION, 2001, 3 (14-15) :1223-1231
[8]   Blood monocytes consist of two principal subsets with distinct migratory properties [J].
Geissmann, F ;
Jung, S ;
Littman, DR .
IMMUNITY, 2003, 19 (01) :71-82
[9]   Immunosuppression during acute Trypanosoma cruzi infection:: involvement of Ly6G (Gr1+)CD11b+ immature myeloid suppressor cells [J].
Goñi, O ;
Alcaide, P ;
Fresno, M .
INTERNATIONAL IMMUNOLOGY, 2002, 14 (10) :1125-1134
[10]   Dynamics of macrophage cell populations during murine pulmonary tuberculosis [J].
Gonzalez-Juarrero, M ;
Shim, TS ;
Kipnis, A ;
Junquieira-Kipnis, AP ;
Orme, IM .
JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :3128-3135
1234