Thin-Layer Chromatography in the Analysis of Biologically Active Ionic and Ionizable Compounds

被引：4

作者：

Petruczynik, Anna ^{[1
]}

Ciesla, Lukasz M. ^{[1
,2
]}

机构：

[1] Med Univ Lublin, Dept Inorgan Chem, PL-20093 Lublin, Poland

[2] NIA, Lab Clin Invest, NIH, Baltimore, MD 21224 USA

来源：

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 2015年 / 28卷 / 06期

关键词：

Review; Ionic compounds; Weak electrolytes; Alkaloids; Phenolic acids; INDICATING HPTLC METHOD; BONDED STATIONARY PHASES; TLC-DENSITOMETRIC METHOD; QUANTITATIVE-ANALYSIS; HUMAN SERUM; BULK DRUG; PLANAR CHROMATOGRAPHY; SCANNING DENSITOMETRY; LIQUID-CHROMATOGRAPHY; OLMESARTAN MEDOXOMIL;

D O I：

10.1556/1006.2015.28.6.1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ionic and ionizable solutes constitute a large group of compounds characterized with biological activity. Chromatographic analysis of these compounds is more difficult when compared to nonionic substances. This review focuses on different approaches used for the separation of basic and acidic substances by means of thin-layer chromatography. Biologically active basic compounds are more often used as prescribed drugs; therefore, chromatographic analysis of these substances was described in more detail when compared to acidic solutes. Direct stimulus to write this review was the 65th anniversary of Prof. Monika Waksmundzka-Hajnos' birthday. Prof. Hajnos is known for her great contributions to chromatographic analysis of ionic solutes.

引用

页码：413 / 425

页数：13

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