MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons

被引：222
作者：
Kowall, NW [1 ]
Hantraye, P
Brouillet, E
Beal, MF
McKee, AC
Ferrante, RJ
机构：
[1] Vet Affairs Med Ctr, Geriatr Res Educ Clin Ctr, Bedford, MA 01730 USA
[2] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA
[3] Boston Univ, Sch Med, Dept Pathol, Boston, MA 02215 USA
[4] CEA, Serv Hosp Frederic Joliot, CNRS, URA 2210, F-91406 Orsay, France
[5] Massachusetts Gen Hosp, Neurol Serv, Neurochem Lab, Boston, MA 02114 USA
[6] Harvard Univ, Sch Med, Boston, MA USA
来源：
NEUROREPORT | 2000年 / 11卷 / 01期
关键词：
baboon; MPTP; synuclein; substantia nigra;
D O I：
10.1097/00001756-200001170-00041
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
1-Methyl-4-phenyl-1,2,3,6-retrahydropyridine (MPTP) neurotoxicity reproduces many of the features of Parkinson's disease (PD). alpha-Synuclein has been identified as a prominent component of the Lewy body (LB), the pathological hallmark of PD. MPTP-treated primates have been reported to develop intraneuronal inclusions but not true Lewy bodies. We administered MPTP to baboons and used a monoclonal alpha-synuclein antibody to define the relationship between neuronal degeneration and alpha-synuclein immunoreactivity in the substantia nigra. MPTP-induced neuronal degeneration was associated with the redistribution of alpha-synuclein from its normal synaptic location to aggregates in degenerating neuronal cell bodies. alpha-Synuclein aggregation induced by MPTP models the early stages of Lewy body formation and may be a fundamental step in the evolution of neuronal degeneration in PD. NeuroReport 11:211-213 (C) 2000 Lippincott Williams & Wilkins.
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收藏
页码：211 / 213
页数：3
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