Marital status and survival in patients with rectal cancer: An analysis of the Surveillance, Epidemiology and End Results (SEER) database

被引:53
作者
Wang, Xiangyang [1 ]
Cao, Weilan [1 ]
Zheng, Chenguo [1 ]
Hu, Wanle [1 ]
Liu, Changbao [1 ]
机构
[1] Wenzhou Med Univ, Dept Coloproctol, Affiliated Hosp 2, 109 Xueyuan West Rd, Wenzhou, Peoples R China
关键词
Rectal neoplasms; Marital status; Cancer survival; SEER; PSYCHOLOGICAL DISTRESS; STRESS; DIAGNOSIS; IMPACT; COLON; STAGE; STATISTICS; MECHANISMS; MARRIAGE;
D O I
10.1016/j.canep.2018.04.007
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Marital status has been validated as an independent prognostic factor for survival in several cancer types, but is controversial in rectal cancer (RC). The objective of this study was to investigate the impact of marital status on the survival outcomes of patients with RC. Methods: We extracted data of 27,498 eligible patients diagnosed with RC between 2004 and 2009 from the Surveillance, Epidemiology and End Results (SEER) database. Patients were categorized into married, never married, divorced/separated and widowed groups.We used Chi-square tests to compare characteristics of patients with different marital status.Rectal cancer specific survival was compared using the Kaplan-Meier method,and multivariate Cox regression analyses was used to analyze the survival outcome risk factors in different marital status. Results: The widowed group had the highest percentage of elderly patients and women,higher proportion of adenocarcinomas, and more stage I/II in tumor stage (P < 0.05),but with a lower rate of surgery compared to the married group (76.7% VS 85.4%). Compared with the married patients, the never married (HR 1.40), widowed (HR 1.61,) and divorced/separated patients (HR 1.16) had an increased overall 5-year mortality. A further analysis showed that widowed patients had an increased overall 5-year cause-specific survival(CSS) compared with married patients at stage I(HR 1.92),stage II (HR 1.65),stage III (HR 1.73),and stage IV (HR 1.38). Conclusion: Our study showed marriage was associated with better outcomes of RC patients, but unmarried RC patients, especially widowed patients,are at greater risk of cancer specific mortality.
引用
收藏
页码:119 / 124
页数:6
相关论文
共 50 条
[41]   Comparison of Survival among Colon Cancer Patients in the US Military Health System and Patients in the Surveillance, Epidemiology, and End Results (SEER) Program [J].
Lin, Jie ;
McGlynn, Katherine A. ;
Shriver, Craig D. ;
Zhu, Kangmin .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2021, 30 (07) :1359-1365
[42]   Cancer survival and incidence from the surveillance, epidemiology, and end results (SEER) program [J].
Ries, LAG ;
Reichman, ME ;
Lewis, DR ;
Hankey, BF ;
Edwards, BK .
ONCOLOGIST, 2003, 8 (06) :541-552
[43]   Deep learning models for predicting the survival of patients with hepatocellular carcinoma based on a surveillance, epidemiology, and end results (SEER) database analysis [J].
Wang, Shoucheng ;
Shao, Mingyi ;
Fu, Yu ;
Zhao, Ruixia ;
Xing, Yunfei ;
Zhang, Liujie ;
Xu, Yang .
SCIENTIFIC REPORTS, 2024, 14 (01)
[44]   Marital status and survival in patients with gastric cancer [J].
Jin, Jie-Jie ;
Wang, Wei ;
Dai, Fa-Xiang ;
Long, Zi-Wen ;
Cai, Hong ;
Liu, Xiao-Wen ;
Zhou, Ye ;
Huang, Hua ;
Wang, Ya-Nong .
CANCER MEDICINE, 2016, 5 (08) :1821-1829
[45]   The effect of metastasis patterns on survival in male patients with different breast cancer subtypes: results from the Surveillance, Epidemiology, and End Results (SEER) database [J].
Zhou, Wei ;
Wang, Shi-Pei ;
Zeng, Wen ;
Chen, Si-Chao ;
Huang, Yi-Hui ;
Zhou, Ling ;
Wang, Min ;
Wei, Wei ;
Zhang, Chao ;
Liu, Ze-Ming ;
Guo, Liang .
TRANSLATIONAL CANCER RESEARCH, 2020, 9 (04) :2267-+
[46]   Lymph Node Identification Following Neoadjuvant Therapy in Rectal Cancer: A Stage-Stratified Analysis using the Surveillance, Epidemiology, and End Results (SEER)-Medicare Database [J].
Ecker, Brett L. ;
Paulson, Emily C. ;
Datta, Jashodeep ;
Jeganathan, Arjun N. ;
Aarons, Cary ;
Kelz, Rachel R. ;
Mahmoud, Najjia N. .
JOURNAL OF SURGICAL ONCOLOGY, 2015, 112 (04) :415-420
[47]   Marital status, an independent predictor for survival of gastric neuroendocrine neoplasm patients: a SEER database analysis [J].
Zhou, Yu-Jie ;
Lu, Xiao-Fan ;
Zheng, Kenneth, I ;
Wang, Qi-Wen ;
Chen, Jin-Nan ;
Zhang, Qing-Wei ;
Yan, Fang-Rong ;
Li, Xiao-Bo .
BMC ENDOCRINE DISORDERS, 2020, 20 (01)
[48]   Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database [J].
Li, Mu ;
Dai, Chen-Yang ;
Wang, Yu-Ning ;
Chen, Tao ;
Wang, Long ;
Yang, Ping ;
Xie, Dong ;
Mao, Rui ;
Chen, Chang .
ONCOTARGET, 2016, 7 (47) :77152-77162
[49]   The influence of marital status on the survival of patients with operable gastrointestinal stromal tumor: A SEER-based study [J].
Chen, Mo ;
Wang, Xuan ;
Wei, Ran ;
Wang, Zheng .
INTERNATIONAL JOURNAL OF HEALTH PLANNING AND MANAGEMENT, 2019, 34 (01) :E447-E463
[50]   Marital Status and Stage at Diagnosis of Cutaneous Melanoma Results From the Surveillance Epidemiology and End Results (SEER) Program, 1973-2006 [J].
McLaughlin, John M. ;
Fisher, James L. ;
Paskett, Electra D. .
CANCER, 2011, 117 (09) :1984-1993