Successful rituximab treatment of refractory hemophagocytic lymphohistiocytosis and autoimmune hemolytic anemia associated with systemic lupus erythematosus

被引：18
作者：
So, Min Wook [1 ]
Koo, Bon San [1 ]
Kim, You Jae [1 ]
Kim, Yong-Gil [1 ]
Lee, Chang-Keun [1 ]
Yoo, Bin [1 ]
机构：
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Div Rheumatol,Dept Internal Med, Seoul, South Korea
来源：
MODERN RHEUMATOLOGY | 2014年 / 24卷 / 05期
关键词：
Hemophagocytic lymphohistiocytosis; Systemic lupus erythematosus; Rituximab; Refractory; DISEASES; THERAPY; PATIENT;
D O I：
10.3109/14397595.2013.874740
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
High-dose steroids, immunosuppressants such as cyclophosphamide and cyclosporine, and high-dose intravenous immunoglobulin have all been used to control hemophagocytic lymphohistiocytosis (HLH) or autoimmune hemolytic anemia (AIHA) associated with systemic lupus erythematosus (SLE); however, some patients are refractory to treatment. Rituximab has successfully resolved many of the refractory manifestations of SLE. Here, we report a case of HLH and AIHA associated with SLE that was refractory or intolerable to conventional therapy, but was successfully treated with rituximab.
引用
收藏
页码：855 / 857
页数：3
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