Estimating the size of the bacterial pan-genome

被引：225

作者：

Lapierrel, Pascal ^{[1
]}

Gogarten, J. Peter ^{[2
]}

机构：

[1] Univ Connecticut, Ctr Biotechnol, Storrs, CT 06269 USA

[2] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA

来源：

TRENDS IN GENETICS | 2009年 / 25卷 / 03期

关键词：

PROTEIN FAMILIES; EVOLUTION; TRANSPORTERS; PATTERNS; GENES;

D O I：

10.1016/j.tig.2008.12.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The 'pan-genome' denotes the set of all genes present in the genomes of a group of organisms. Here, we extend the pan-genome concept to higher taxonomic units. Using 573 sequenced genomes, we estimate the size of the bacterial pan-genome based on the frequency of occurrences of genes among sampled genomes. Using gene- and genome-centered approaches, we characterize three distinct pools of gene families that comprise the bacterial pan-genome, each evolving under different evolutionary constraints. Our findings indicate that the pan-genome of the bacterial domain is of infinite size (the Bacteria as a whole have an open pan-genome) and that similar to 250 genes per genome belong to the extended bacterial core genome.

引用

页码：107 / 110

页数：4

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