A Molecular Circuit Regenerator to Implement Iterative Strand Displacement Operations

被引：19

作者：

DelRosso, Nicole V. ^{[2
]}

Hews, Sarah ^{[2
]}

Spector, Lee ^{[3
]}

Derr, Nathan D. ^{[1
]}

机构：

[1] Smith Coll, Dept Biol Sci, Northampton, MA 01063 USA

[2] Hampshire Coll, Sch Nat Sci, Amherst, MA 01002 USA

[3] Hampshire Coll, Sch Cognit Sci, Amherst, MA 01002 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 16期

基金：

美国国家科学基金会;

关键词：

DNA computing; molecular devices; nanotechnology; nucleic acids; strand displacement; COMPUTATION;

D O I：

10.1002/anie.201610890

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The predictable chemistry of Watson-Crick basepairing imparts a unique structural programmability to DNA, enabling the facile design of molecular reactions that perform computations. However, many of the current architectures limit devices to a single operational cycle. Herein, we introduce the design of the "regenerator", a device based on coupled enthalpic and entropic reactions that permits the regeneration of molecular circuit components.

引用

页码：4443 / 4446

页数：4

共 18 条

[1] An Analog Chemical Circuit with Parallel-Accessible Delay Line for Learning Temporal Tasks [J].

Banda, Peter ;

Teuscher, Christof .

ALIFE 2014: THE FOURTEENTH INTERNATIONAL CONFERENCE ON THE SYNTHESIS AND SIMULATION OF LIVING SYSTEMS, 2014, :482-489

[2] Training an asymmetric signal perceptron through reinforcement in an artificial chemistry [J].

Banda, Peter ;

Teuscher, Christof ;

Stefanovic, Darko .

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2014, 11 (93)

[3] An autonomous molecular computer for logical control of gene expression [J].

Benenson, Y ;

Gil, B ;

Ben-Dor, U ;

Adar, R ;

Shapiro, E .

NATURE, 2004, 429 (6990) :423-429

[4] Strand algebras for DNA computing [J].

Cardelli, Luca .

NATURAL COMPUTING, 2011, 10 (01) :407-428

[5] Scaling down DNA circuits with competitive neural networks [J].

Genot, Anthony J. ;

Fujii, Teruo ;

Rondelez, Yannick .

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2013, 10 (85)

[6] Combinatorial Displacement of DNA Strands: Application to Matrix Multiplication and Weighted Sums [J].

Genot, Anthony J. ;

Bath, Jonathan ;

Turberfield, Andrew J. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (04) :1189-1192

[7] Reversible Logic Circuits Made of DNA [J].

Genot, Anthony J. ;

Bath, Jonathan ;

Turberfield, Andrew J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (50) :20080-20083

[8]

Kim J., 2004, NIPS, P681

[9] Nucleic Acid Based Molecular Devices [J].

Krishnan, Yamuna ;

Simmel, Friedrich C. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (14) :3124-3156

[10] Supervised Learning in Adaptive DNA Strand Displacement Networks [J].

Lakin, Matthew R. ;

Stefanovic, Darko .

ACS SYNTHETIC BIOLOGY, 2016, 5 (08) :885-897

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