PBRM1 Regulates Stress Response in Epithelial Cells

被引：24

作者：

Porter, Elizabeth G. ^{[1
]}

Dhiman, Alisha ^{[1
]}

Chowdhury, Basudev ^{[1
]}

Carter, Benjamin C. ^{[1
]}

Lin, Hang ^{[1
]}

Stewart, Jane C. ^{[1
]}

Kazemian, Majid ^{[2
]}

Wendt, Michael K. ^{[1
]}

Dykhuizen, Emily C. ^{[1
]}

机构：

[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47906 USA

[2] Purdue Univ, Dept Biochem, W Lafayette, IN 47906 USA

来源：

ISCIENCE | 2019年 / 15卷

关键词：

TRANSCRIPTION FACTORS; H3K14; ACETYLATION; CHROMATIN; SWI/SNF; HISTONE; REGIONS; BAF180; MODEL; IDENTIFICATION; TRANSFORMATION;

D O I：

10.1016/j.isci.2019.04.027

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Polybromo1 (PBRM1) is a chromatin remodeler subunit highly mutated in cancer, particularly clear cell renal carcinoma. PBRM1 is a member of the SWI/SNF subcomplex, PBAF (PBRM1-Brg1/Brm-associated factors), and is characterized by six tandem bromodomains. Here we establish a role for PBRM1 in epithelial cell maintenance through the expression of genes involved in cell adhesion, metabolism, stress response, and apoptosis. In support of a general role for PBRM1 in stress response and apoptosis, we observe that loss of PBRM1 results in an increase in reactive oxygen species generation and a decrease in cellular viability under stress conditions. We find that loss of PBRM1 promotes cell growth under favorable conditions but is required for cell survival under conditions of cellular stress.

引用

页码：196 / +

页数：29

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