Complications associated with genetic background effects in research using knockout mice

被引:129
作者
Phillips, TJ
Hen, R
Crabbe, JC
机构
[1] Oregon Hlth Sci Univ, Vet Affairs Med Ctr, Portland, OR 97201 USA
[2] Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA
[3] Portland Alcohol Res Ctr, Portland, OR 97201 USA
[4] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA
关键词
D O I
10.1007/s002130051128
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
[No abstract available]
引用
收藏
页码:5 / 7
页数:3
相关论文
共 15 条
[1]   GENETIC DISSECTION OF BEHAVIOR [J].
BENZER, S .
SCIENTIFIC AMERICAN, 1973, 229 (06) :24-37
[2]   Genetics of mouse behavior: Interactions with laboratory environment [J].
Crabbe, JC ;
Wahlsten, D ;
Dudek, BC .
SCIENCE, 1999, 284 (5420) :1670-1672
[3]   Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors [J].
Crabbe, JC ;
Phillips, TJ ;
Feller, DJ ;
Hen, R ;
Wenger, CD ;
Lessov, CN ;
Schafer, GL .
NATURE GENETICS, 1996, 14 (01) :98-101
[4]   Unusual behavioral phenotypes of inbred mouse strains - Commentary [J].
Crawley, JN .
TRENDS IN NEUROSCIENCES, 1996, 19 (05) :181-182
[5]   Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior [J].
El-Ghundi, M ;
George, SR ;
Drago, J ;
Fletcher, PJ ;
Fan, T ;
Nguyen, T ;
Liu, C ;
Sibley, DR ;
Westphal, H ;
O'Dowd, BF .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 353 (2-3) :149-158
[6]   Gene-targeting studies of mammalian behavior: Is it the mutation or the background genotype? [J].
Gerlai, R .
TRENDS IN NEUROSCIENCES, 1996, 19 (05) :177-181
[7]   MUTANT MICE LACKING THE GAMMA-ISOFORM OF PROTEIN-KINASE-C SHOW DECREASED BEHAVIORAL ACTIONS OF ETHANOL AND ALTERED FUNCTION OF GAMMA-AMINOBUTYRATE TYPE-A RECEPTORS [J].
HARRIS, RA ;
MCQUILKIN, SJ ;
PAYLOR, R ;
ABELIOVICH, A ;
TONEGAWA, S ;
WEHNER, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3658-3662
[8]   Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice [J].
Heisler, LK ;
Chu, HM ;
Brennan, TJ ;
Danao, JA ;
Bajwa, P ;
Parsons, LH ;
Tecott, LH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :15049-15054
[9]  
Kelly MA, 1998, J NEUROSCI, V18, P3470
[10]  
LUNA RMD, 1995, NATURE, V378, P203