High Serum Level of Antithymocyte Globulin Immediately before Graft Infusion Is Associated with a Low Likelihood of Chronic, But Not Acute, Graft-versus-Host Disease

被引：20

作者：

Chawla, Sumit ^{[1
,2
]}

Dharmani-Khan, Poonam ^{[1
]}

Liu, Yiping ^{[1
]}

Prokopishyn, Nicole ^{[1
]}

Munir, Muhammad Amlish ^{[1
]}

Griffiths, Cameron ^{[1
]}

Khan, Faisal M. ^{[1
]}

Stewart, Douglas A. ^{[1
]}

Russell, James A. ^{[1
]}

Daly, Andrew ^{[1
]}

Storek, Jan ^{[1
]}

机构：

[1] Univ Calgary, Calgary, AB T2N 4N1, Canada

[2] Univ Copenhagen, DK-1168 Copenhagen, Denmark

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2014年 / 20卷 / 08期

关键词：

Antithymocyte globulin; Acute GVHD; Chronic GVHD; STEM-CELL TRANSPLANTATION; MATCHED UNRELATED DONORS; ANTI-THYMOCYTE GLOBULIN; RANDOMIZED-TRIAL; THYMOGLOBULIN; PROPHYLAXIS; RECIPIENTS; FLUDARABINE; MECHANISMS; MORTALITY;

D O I：

10.1016/j.bbmt.2014.04.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rabbit antithymocyte globulin (ATG) is administered during transplant conditioning to decrease the risk of both acute graft-versus-host disease (aGVHD) and chronic graft-versus-host disease (cGVHD). Here we evaluated the relationship between the serum concentration of ATG (capable of binding to lymphocytes) immediately before graft infusion (day p) or on day +7 or +28 post-transplantation and the development of aGVHD or cGVHD. We studied 180 patients whose conditioning included 4.5 mg/kg antithymocyte globulin (ATG; Thymoglobulin). For aGVHD, we found no association with ATG levels on day 0. Nevertheless, high day +7 and +28 ATG levels were associated with a low likelihood of aGVHD. For cGVHD, high ATG levels at all 3 time points (days 0, +7, and +28) were associated with a low likelihood of cGVHD. In conclusion, high-dose ATG administration at the time of graft infusion appears to inhibit the development of cGVHD, but not aGVHD; however, higher ATG levels on days +7 and +28 are associated with lower rates of both aGVHD and cGVHD. (C) 2014 American Society for Blood and Marrow Transplantation.

引用

页码：1156 / 1162

页数：7

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