Phospholipase C

被引：42
作者：
Vines, Charlotte M. [1 ]
机构：
[1] Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66160 USA
来源：
CALCIUM SIGNALING | 2012年 / 740卷
关键词：
Calcium; Diacyl glycerol; Heterotrimeric G protein; Inositol triphosphate; Isoforms; Isozymes; Phosphatidyl inositol; Phospholipase C; Signal transduction; Structure; PLECKSTRIN HOMOLOGY DOMAIN; TRIGGERS CA2+ OSCILLATIONS; BASIC-AMINO-ACIDS; NUCLEAR-LOCALIZATION; GENOMIC ORGANIZATION; DEPENDENT ACTIVATION; MOLECULAR-CLONING; TYROSINE RESIDUES; CRYSTAL-STRUCTURE; MULTIPLE FORMS;
D O I：
10.1007/978-94-007-2888-2_10
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate diverse functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times each isoform, contributes to unique cellular functions. This chapter provides a review of the current literature. In addition, references have been provided for more in depth information regarding areas that are discussed. Ultimately, understanding the roles of the individual PLC enzymes, and their distinct cellular functions, will lead to a better understanding of the development of diseases and the maintenance of homeostasis
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页码：235 / 254
页数：20
相关论文
共 138 条
  • [1] A unique isoform of phospholipase Cβ4 highly expressed in the cerebellum and eye
    Adamski, FM
    Timms, KM
    Shieh, BH
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1444 (01): : 55 - 60
  • [2] Disruption of phospholipase Cδ4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C
    Akutagawa, Atsushi
    Fukami, Kiyoko
    Banno, Yoshiko
    Takenawa, Tadaomi
    Kannagi, Reiji
    Yokoyama, Yukihiro
    Oda, Koji
    Nagino, Masato
    Nimura, Yuji
    Yoshida, Shonen
    Tamiya-Koizumi, Keiko
    [J]. JOURNAL OF BIOCHEMISTRY, 2006, 140 (05) : 619 - 625
  • [3] INFLUENCE OF PHOSPHOLIPASE C ON SOME ELECTRICAL PROPERTIES OF SKELETAL MUSCLE MEMBRANE
    ALBUQUERQUE, EX
    THESLEFF, S
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1967, 190 (01): : 123 - +
  • [4] Regulation of inositol lipid-specific phospholipase C delta by changes in Ca2+ ion concentrations
    Allen, V
    Swigart, P
    Cheung, R
    Cockcroft, S
    Katan, M
    [J]. BIOCHEMICAL JOURNAL, 1997, 327 : 545 - 552
  • [5] CDNA SEQUENCE AND GENE LOCUS OF THE HUMAN RETINAL PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE-C-BETA-4 (PLCB4)
    ALVAREZ, RA
    GHALAYINI, AJ
    XU, P
    HARDCASTLE, A
    BHATTACHARYA, S
    RAO, PN
    PETTENATI, MJ
    ANDERSON, RE
    BAEHR, W
    [J]. GENOMICS, 1995, 29 (01) : 53 - 61
  • [6] SH3 DOMAINS DIRECT CELLULAR-LOCALIZATION OF SIGNALING MOLECULES
    BARSAGI, D
    ROTIN, D
    BATZER, A
    MANDIYAN, V
    SCHLESSINGER, J
    [J]. CELL, 1993, 74 (01) : 83 - 91
  • [7] PHOSPHOLIPASE C-BETA-1 IS A GTPASE-ACTIVATING PROTEIN FOR GQ/11, ITS PHYSIOLOGICAL REGULATOR
    BERSTEIN, G
    BLANK, JL
    JHON, DY
    EXTON, JH
    RHEE, SG
    ROSS, EM
    [J]. CELL, 1992, 70 (03) : 411 - 418
  • [8] Recruitment and activation of PLCγ1 in T cells:: a new insight into old domains
    Braiman, A
    Barda-Saad, M
    Sommers, CL
    Samelson, LE
    [J]. EMBO JOURNAL, 2006, 25 (04) : 774 - 784
  • [9] PLC regulation: emerging pictures for molecular mechanisms
    Bunney, Tom D.
    Katan, Matilda
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2011, 36 (02) : 88 - 96
  • [10] ISOZYME-SELECTIVE STIMULATION OF PHOSPHOLIPASE C-BETA-2 BY G-PROTEIN BETA-GAMMA-SUBUNITS
    CAMPS, M
    CAROZZI, A
    SCHNABEL, P
    SCHEER, A
    PARKER, PJ
    GIERSCHIK, P
    [J]. NATURE, 1992, 360 (6405) : 684 - 686
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