Harnessing ruthenium(II) as photodynamic agents: Encouraging advances in cancer therapy

被引：170
作者：
Liu, Jiangping [1 ]
Zhang, Chen [1 ]
Rees, Thomas W. [1 ]
Ke, Libing [1 ]
Ji, Liangnian [1 ]
Chao, Hui [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China
[2] Hunan Univ Sci & Technol, MOE Key Lab Theoret Organ Chem & Funct Mol, Sch Chem & Chem Engn, Xiangtan 400201, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2018年 / 363卷
基金：
美国国家科学基金会;
关键词：
Ruthenium(II) complexes; Supramolecular systems; Nanomaterials; Photodynamic therapy; RU(II) POLYPYRIDYL COMPLEXES; TRANSITION-METAL-COMPLEXES; PHOTOINDUCED DNA CLEAVAGE; 2-PHOTON ABSORPTION; RU-II; CELLULAR UPTAKE; EXCITED-STATES; UP-CONVERSION; RED-LIGHT; RU(II)-PT(II) SUPRAMOLECULE;
D O I：
10.1016/j.ccr.2018.03.002
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Despite their past triumphs, platinum-based therapeutics remain limited by chemo-resistance and severe side effects. As an alternative therapeutic modality which bypasses these issues, photodynamic therapy (PDT) holds great promise. The first FDA approved PDT agent, Photofrin, stimulated an outpouring of porphyrin-motif studies, while metallodrugs have long been underappreciated in this area. Due to their unique and versatile properties, ruthenium complexes are receiving increasing attention in the field of PDT. Herein, we introduce the recent advances in Ru(II)-based PDT agents ranging from single molecules to delicate nanomaterials, how these agents are unique suited to PDT and the merits provided by their various forms. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：17 / 28
页数：12
相关论文
共 156 条
[21]   Fine control on the photochemical and photobiological properties of Ru(II) arene complexes [J].
Chen, Yongjie ;
Lei, Wanhua ;
Hou, Yuanjun ;
Li, Chao ;
Jiang, Guoyu ;
Zhang, Baowen ;
Zhou, Qianxiong ;
Wang, Xuesong .
DALTON TRANSACTIONS, 2015, 44 (16) :7347-7354
[22]   Fusion of photodynamic therapy and photoactivated chemotherapy: a novel Ru(II) arene complex with dual activities of photobinding and photocleavage toward DNA [J].
Chen, Yongjie ;
Lei, Wanhua ;
Jiang, Guoyu ;
Hou, Yuanjun ;
Li, Chao ;
Zhang, Baowen ;
Zhou, Qianxiong ;
Wang, Xuesong .
DALTON TRANSACTIONS, 2014, 43 (41) :15375-15384
[23]   Two-photon luminescent metal complexes for bioimaging and cancer phototherapy [J].
Chen, Yu ;
Guan, Ruilin ;
Zhang, Chen ;
Huang, Juanjuan ;
Ji, Liangnian ;
Chao, Hui .
COORDINATION CHEMISTRY REVIEWS, 2016, 310 :16-40
[24]   An upconversion nanoparticle/Ru(II) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent [J].
Chen, Yumeng ;
Jiang, Guoyu ;
Zhou, Qianxiong ;
Zhang, Yangyang ;
Li, Ke ;
Zheng, Yue ;
Zhang, Baowen ;
Wang, Xuesong .
RSC ADVANCES, 2016, 6 (28) :23804-23808
[25]   Blood-vessel closure using photosensitizers engineered for two-photon excitation [J].
Collins, Hazel A. ;
Khurana, Mamta ;
Moriyama, Eduardo H. ;
Mariampillai, Adrian ;
Dahlstedt, Emma ;
Balaz, Milan ;
Kuimova, Marina K. ;
Drobizhev, Mikhail ;
Yang, Victor X. D. ;
Phillips, David ;
Rebane, Aleksander ;
Wilson, Brian C. ;
Anderson, Harry L. .
NATURE PHOTONICS, 2008, 2 (07) :420-424
[26]  
Cortese DA, 1997, MAYO CLIN PROC, V72, P595
[27]   Photodynamic Inactivation of Mammalian Viruses and Bacteriophages [J].
Costa, Liliana ;
Faustino, Maria Amparo F. ;
Neves, Maria Graca P. M. S. ;
Cunha, Angela ;
Almeida, Adelaide .
VIRUSES-BASEL, 2012, 4 (07) :1034-1074
[28]   Tris-ruthenium(II)/copper(II) multimetallic porphyrin: Synthesis, characterization, DNA binding and supercoiled DNA photocleavage studies [J].
Craver, Emily ;
McCrate, Anna ;
Nielsen, Mark ;
Swavey, Shawn .
INORGANICA CHIMICA ACTA, 2010, 363 (02) :453-456
[29]   Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer [J].
Dickerson, Matthew ;
Howerton, Brock ;
Bae, Younsoo ;
Glazer, Edith C. .
JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (03) :394-408
[30]   Modifying Charge and Hydrophilicity of Simple Ru(II) Polypyridyl Complexes Radically Alters Biological Activities: Old Complexes, Surprising New Tricks [J].
Dickerson, Matthew ;
Sun, Yang ;
Howerton, Brock ;
Glazer, Edith C. .
INORGANIC CHEMISTRY, 2014, 53 (19) :10370-10377
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