Harnessing ruthenium(II) as photodynamic agents: Encouraging advances in cancer therapy

被引：170

作者：

Liu, Jiangping ^{[1
]}

Zhang, Chen ^{[1
]}

Rees, Thomas W. ^{[1
]}

Ke, Libing ^{[1
]}

Ji, Liangnian ^{[1
]}

Chao, Hui ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] Hunan Univ Sci & Technol, MOE Key Lab Theoret Organ Chem & Funct Mol, Sch Chem & Chem Engn, Xiangtan 400201, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2018年 / 363卷

基金：

美国国家科学基金会;

关键词：

Ruthenium(II) complexes; Supramolecular systems; Nanomaterials; Photodynamic therapy; RU(II) POLYPYRIDYL COMPLEXES; TRANSITION-METAL-COMPLEXES; PHOTOINDUCED DNA CLEAVAGE; 2-PHOTON ABSORPTION; RU-II; CELLULAR UPTAKE; EXCITED-STATES; UP-CONVERSION; RED-LIGHT; RU(II)-PT(II) SUPRAMOLECULE;

D O I：

10.1016/j.ccr.2018.03.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Despite their past triumphs, platinum-based therapeutics remain limited by chemo-resistance and severe side effects. As an alternative therapeutic modality which bypasses these issues, photodynamic therapy (PDT) holds great promise. The first FDA approved PDT agent, Photofrin, stimulated an outpouring of porphyrin-motif studies, while metallodrugs have long been underappreciated in this area. Due to their unique and versatile properties, ruthenium complexes are receiving increasing attention in the field of PDT. Herein, we introduce the recent advances in Ru(II)-based PDT agents ranging from single molecules to delicate nanomaterials, how these agents are unique suited to PDT and the merits provided by their various forms. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：17 / 28

页数：12

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