New Insight into the Molecular Drug Target of Diabetic Nephropathy

被引：24

作者：

Soetikno, Vivian ^{[1
]}

Arozal, Wawaimuli ^{[1
]}

Louisa, Melva ^{[1
]}

Setiabudy, Rianto ^{[1
]}

机构：

[1] Univ Indonesia, Fac Med, Dept Pharmacol & Therapeut, Jakarta 10430, Indonesia

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2014年 / 2014卷

关键词：

PROTEIN-KINASE-C; ANGIOTENSIN-CONVERTING ENZYME; GLYCATION END-PRODUCTS; RENAL LIPID-METABOLISM; OXIDATIVE STRESS; RENIN-ANGIOTENSIN; LONG-TERM; TGF-BETA; BARDOXOLONE METHYL; MAMMALIAN TARGET;

D O I：

10.1155/2014/968681

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic nephropathy (DN) lowered quality of life and shortened life expectancy amongst those affected. Evidence indicates interaction between advanced glycation end products (AGEs), activated protein kinase C (PKC) and angiotensin II exacerbate the progression of DN. Inhibitors of angiotensin-converting enzyme (ACEIs), renin angiotensin aldosterone system (RAAS), AGEs, and PKC have been tested for slowing down the progression of DN. The exact molecular drug targets that lead to the amelioration of renal injury in DN are not well understood. This review summarizes the potential therapeutic targets, based on putative mechanism in the progression of the disease.

引用

页数：9

共 105 条

[1] HIGH GLUCOSE INCREASES DIACYLGLYCEROL MASS AND ACTIVATES PROTEIN-KINASE-C IN MESANGIAL CELL-CULTURES [J].

AYO, SH ;

RADNIK, R ;

GARONI, JA ;

TROYER, DA ;

KREISBERG, JI .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (04) :F571-F577

[2] Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells [J].

Babazono, T ;

Kapor-Drezgic, J ;

Dlugosz, JA ;

Whiteside, C .

DIABETES, 1998, 47 (04) :668-676

[3] Smad3-ATF3 signaling mediates TGF-β suppression of genes encoding Phase II detoxifying proteins [J].

Bakin, AV ;

Stourman, NV ;

Sekhar, KR ;

Rinehart, C ;

Yan, XX ;

Meredith, MJ ;

Arteaga, CL ;

Freeman, ML .

FREE RADICAL BIOLOGY AND MEDICINE, 2005, 38 (03) :375-387

[4] Recognition, Pathogenesis, and Treatment of Different Stages of Nephropathy in Patients With Type 2 Diabetes Mellitus [J].

Bakris, George L. .

MAYO CLINIC PROCEEDINGS, 2011, 86 (05) :444-456

[5] Happy birthday protein kinase C: Past, present and future of a superfarnily [J].

Battaini, Fiorenzo .

PHARMACOLOGICAL RESEARCH, 2007, 55 (06) :461-466

[6] Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats [J].

Bilan, Victor P. ;

Salah, Eman M. ;

Bastacky, Sheldon ;

Jones, Huw B. ;

Mayers, Rachel M. ;

Zinker, Bradley ;

Poucher, Simon M. ;

Tofovic, Stevan P. .

JOURNAL OF ENDOCRINOLOGY, 2011, 210 (03) :293-308

[7] ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis [J].

Blanco, S ;

Bonet, J ;

López, D ;

Casas, I ;

Romero, R .

KIDNEY INTERNATIONAL, 2005, 67 :S10-S14

[8] The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes [J].

Brown, Nicholas F. ;

Stefanovic-Racic, Maja ;

Sipula, Ian J. ;

Perdomo, German .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2007, 56 (11) :1500-1507

[9] The pathobiology of diabetic complications - A unifying mechanism [J].

Brownlee, M .

DIABETES, 2005, 54 (06) :1615-1625

[10] The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation [J].

Bryan, Holly K. ;

Olayanju, Adedamola ;

Goldring, Christopher E. ;

Park, B. Kevin .

BIOCHEMICAL PHARMACOLOGY, 2013, 85 (06) :705-717

← 1 2 3 4 5 6 7 8 9 10 →