A positive look at double-negative thymocytes

被引：155
作者：
Ceredig, R
Rolink, T
机构：
[1] CEA, U548 INSERM, F-38054 Grenoble, France
[2] Univ Basel, Pharmactr, Dept Immunol, CH-4065 Basel, Switzerland
来源：
NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 11期
关键词：
D O I：
10.1038/nri937
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In some respects, our understanding of the cellular and molecular aspects of early T-cell differentiation is lagging behind that of B cells. Papers describing gene-knockout and reporter-transgenic mice in which thymocyte development is affected are often difficult to interpret. Progress in this field will be hampered unless a more detailed phenotypic and molecular analysis of progenitor thymocytes at the single-cell level is carried out.
引用
收藏
页码：888 / 896
页数：9
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