Ulinastatin downregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury
被引:99
作者:
Li, Xiaofang
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Hebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Li, Xiaofang
[1
]
Su, Likai
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Hebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Su, Likai
[1
]
Zhang, Xiangjian
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机构:
Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Zhang, Xiangjian
[2
,3
]
Zhang, Cong
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机构:
Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Zhang, Cong
[2
,3
]
Wang, Lina
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机构:
Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Wang, Lina
[2
,3
]
Li, Yaoru
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机构:
Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Li, Yaoru
[2
,3
]
Zhang, Ye
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机构:
Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Zhang, Ye
[2
,3
]
He, Tingting
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机构:
Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
He, Tingting
[2
,3
]
Zhu, Xingyuan
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机构:
Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Zhu, Xingyuan
[2
,3
]
Cui, Lili
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机构:
Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R ChinaHebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
Cui, Lili
[2
,3
]
机构:
[1] Hebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China
[2] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Peoples R China
[3] Hebei Med Univ, Hosp 2, Hebei Key Lab Neurol, Shijiazhuang, Peoples R China
Background: Inflammatory damage plays an important role in ischemic stroke and provides potential targets for therapy. Ulinastatin (UTI), a drug used to treat shock and acute pancreatitis in clinic, has attracted attention for its protective effects through immunomodulatory and anti-inflammatory properties. However, the effect of UTI in the acute phase of cerebral ischemia/reperfusion (I/R) is not clear. This study is to investigate the potential neuroprotective effect of UTI and explore its underlying mechanisms. Methods: Male CD-1 mice were subjected to transient middle cerebral artery occlusion (tMCAO) and randomly assigned into four groups: Sham (sham-operated) group, tMCAO (tMCAO+ 0.9% saline) group, UTI-L (tMCAO+UTI 1500 U/100g), and UTI-H (tMCAO+UTI 3000 U/100g) group. UTI was administered immediately after reperfusion in the UTI-L and UTI-H groups. About 24h after the reperfusion, the neurological deficit, brain water content, and infarct volume were detected. Immunohistochemistry, western blot and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to detect the expression of TLR4 and NF-B in the ischemic cerebral cortex. Results: Compared with tMCAO group, both UTI-L and UTI-H groups dramatically ameliorated neurological deficit (p<0.05), lessened the brain water content (p<0.05) and infarct volume (p<0.05), and decreased the expression of TLR4 and NF-B.Conclusion: These results showed that UTI protected the brain against ischemic injury which may be due to the alleviation of inflammation reaction in early stage through downregulating TLR4 and NF-B expression.
机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Blohmke, Christoph J.
Park, Julie
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机构:
Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Providence Heart & Lung Inst, Vancouver, BC V5Z 1M9, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Park, Julie
Hirschfeld, Aaron F.
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机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Hirschfeld, Aaron F.
Victor, Rachel E.
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机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Victor, Rachel E.
Schneiderman, Julia
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Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Schneiderman, Julia
Stefanowicz, Dorota
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机构:
Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Providence Heart & Lung Inst, Vancouver, BC V5Z 1M9, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Stefanowicz, Dorota
Chilvers, Mark A.
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机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Chilvers, Mark A.
Durie, Peter R.
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机构:
Hosp Sick Children, Program Physiol & Expt Med, Toronto, ON M5G 1X8, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Durie, Peter R.
Corey, Mary
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Hosp Sick Children, Child Hlth Evaluat Sci Program, Toronto, ON M5G 1X8, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Corey, Mary
Zielenski, Julian
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Hosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Zielenski, Julian
Dorfman, Ruslan
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机构:
Hosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Dorfman, Ruslan
Sandford, Andrew J.
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机构:
Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Providence Heart & Lung Inst, Vancouver, BC V5Z 1M9, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Sandford, Andrew J.
Daley, Denise
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机构:
Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Providence Heart & Lung Inst, Vancouver, BC V5Z 1M9, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Daley, Denise
Turvey, Stuart E.
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机构:
British Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Blohmke, Christoph J.
Park, Julie
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Providence Heart & Lung Inst, Vancouver, BC V5Z 1M9, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Park, Julie
Hirschfeld, Aaron F.
论文数: 0引用数: 0
h-index: 0
机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Hirschfeld, Aaron F.
Victor, Rachel E.
论文数: 0引用数: 0
h-index: 0
机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Victor, Rachel E.
Schneiderman, Julia
论文数: 0引用数: 0
h-index: 0
机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Schneiderman, Julia
Stefanowicz, Dorota
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Providence Heart & Lung Inst, Vancouver, BC V5Z 1M9, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Stefanowicz, Dorota
Chilvers, Mark A.
论文数: 0引用数: 0
h-index: 0
机构:
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Chilvers, Mark A.
Durie, Peter R.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sick Children, Program Physiol & Expt Med, Toronto, ON M5G 1X8, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Durie, Peter R.
Corey, Mary
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sick Children, Child Hlth Evaluat Sci Program, Toronto, ON M5G 1X8, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Corey, Mary
Zielenski, Julian
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Zielenski, Julian
Dorfman, Ruslan
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Dorfman, Ruslan
Sandford, Andrew J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Providence Heart & Lung Inst, Vancouver, BC V5Z 1M9, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Sandford, Andrew J.
Daley, Denise
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Providence Heart & Lung Inst, Vancouver, BC V5Z 1M9, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Daley, Denise
Turvey, Stuart E.
论文数: 0引用数: 0
h-index: 0
机构:
British Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada
Child & Family Res Inst, Vancouver, BC V5Z 4H4, CanadaBritish Columbia Childrens Hosp, Div Infect & Immunol Dis, Dept Paediat, Vancouver, BC V5Z 4H4, Canada