共 12 条
ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target
被引:54
作者:

Bikeye, Sandra-Nadia Ngwabyt
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机构:
UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Colin, Carole
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机构:
Univ Aix Marseille 2, Fac Med Timone, CRO2, UMR911, Marseille, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Marie, Yannick
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机构:
UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Vampouille, Raphael
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机构:
Univ Paris 06, INSERM, Hop La Pitie Salpetriere,Biotechnol Biotherapy La, Inst Cerveau & Moelle,Ctr Rech,CNRS,UMR9225,UMR 9, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

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Rousseau, Audrey
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机构:
GH Pitie Salpetriere, Serv Neuropathol Raymond Escourolle, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Boisselier, Blandine
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机构:
UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Idbaih, Ahmed
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h-index: 0
机构:
UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France
GH Pitie Salpetriere, APHP, Serv Neurol Mazarin, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Calvo, Charles Felix
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机构:
UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Leuraud, Pascal
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h-index: 0
机构:
XenTech, Evry, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Lassalle, Myriam
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h-index: 0
机构:
XenTech, Evry, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

El Hallani, Soufiane
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h-index: 0
机构:
UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Delattre, Jean-Yves
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h-index: 0
机构:
UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France
GH Pitie Salpetriere, APHP, Serv Neurol Mazarin, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France

Sanson, Marc
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h-index: 0
机构:
UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France
GH Pitie Salpetriere, APHP, Serv Neurol Mazarin, Paris, France UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France
机构:
[1] UPMC, GH Pitie Salpetriere, INSERM, UMR975, Paris, France
[2] Univ Aix Marseille 2, Fac Med Timone, CRO2, UMR911, Marseille, France
[3] GH Pitie Salpetriere, APHP, Serv Neurol Mazarin, Paris, France
[4] Univ Paris 06, INSERM, Hop La Pitie Salpetriere,Biotechnol Biotherapy La, Inst Cerveau & Moelle,Ctr Rech,CNRS,UMR9225,UMR 9, Paris, France
[5] GH Pitie Salpetriere, Serv Neuropathol Raymond Escourolle, Paris, France
[6] XenTech, Evry, France
关键词:
GENE;
GLIOBLASTOMA;
EXPRESSION;
D O I:
10.1186/1475-2867-10-1
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Background: ASPM (Abnormal Spindle-like Microcephaly associated) over-expression was recently implicated in the development of malignant gliomas. Results: To better characterize the involvement of ASPM in gliomas, we investigated the mRNA expression in 175 samples, including 8 WHO Grade II, 75 WHO Grade III and 92 WHO Grade IV tumors. Aspm expression was strongly correlated with tumor grade and increased at recurrence when compared to the initial lesion, whatever the initial grade of the primary tumor. ASPM expression also increased over serial passages in gliomaspheres in vitro and in mouse xenografts in vivo. Lentivirus-mediated shRNA silencing of ASPM resulted in dramatic proliferation arrest and cell death in two different gliomasphere models. Conclusion: These data suggest that ASPM is involved in the malignant progression of gliomas, possibly through expansion of a cancer stem cell compartment, and is an attractive therapeutic target in glioblastoma multiforme.
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Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

Raynal, Virginie
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Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

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Inst Curie, Med Sect, Serv Biostat, F-75231 Paris, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

Hoang-Xuan, Khe
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机构:
INSERM, U711, Paris, France
Univ Paris 06, Lab Biol Interact Neurone Glie, Grp Hosp Pitie Salpetriere, Paris, France
Grp Hosp Pitie Salpetriere, AP HP, Serv Neurol Mazarin, F-75634 Paris, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

Kujas, Michele
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h-index: 0
机构:
INSERM, U711, Paris, France
Univ Paris 06, Lab Biol Interact Neurone Glie, Grp Hosp Pitie Salpetriere, Paris, France
Grp Hosp Pitie Salpetriere, AP HP, Lab Neuropathol R Escourolle, F-75634 Paris, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

Brito, Isabel
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Inst Curie, Sect Rech, Serv Informat, Paris, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

论文数: 引用数:
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Barillot, Emmanuel
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h-index: 0
机构:
Inst Curie, Sect Rech, Serv Informat, Paris, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

Aurias, Alain
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h-index: 0
机构:
Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

Delattre, Jean-Yves
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INSERM, U711, Paris, France
Univ Paris 06, Lab Biol Interact Neurone Glie, Grp Hosp Pitie Salpetriere, Paris, France
Grp Hosp Pitie Salpetriere, AP HP, Serv Neurol Mazarin, F-75634 Paris, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France

Delattre, Olivier
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Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France Inst Curie, INSERM, U830, Unite Genet & Biol Canc,Sect Rech, F-75248 Paris 05, France
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机构: NCI, Lab Biosyst & Canc, Bethesda, MD 20892 USA

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机构: NCI, Lab Biosyst & Canc, Bethesda, MD 20892 USA

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机构: NCI, Lab Biosyst & Canc, Bethesda, MD 20892 USA

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