Localization of insulin receptor-related receptor in the rat kidney

被引：17

作者：

Ozaki, K

Takada, N

Tsujimoto, K

Tsuji, N

Kawamura, T

Muso, E

Ohta, M

Itoh, N

机构：

[1] KYOTO UNIV, FAC PHARMACEUT SCI, DEPT BIOCHEM GENET, KYOTO 60601, JAPAN

[2] KYOTO UNIV, GRAD SCH MED, DEPT CARDIOVASC MED, KYOTO 60601, JAPAN

[3] NATL UTANO HOSP, CLIN RES CTR, KYOTO, JAPAN

来源：

KIDNEY INTERNATIONAL | 1997年 / 52卷 / 03期

关键词：

insulin receptor-related receptor; receptors; cortical collecting duct; growth factor;

D O I：

10.1038/ki.1997.384

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin receptor-related receptor (IRR), a member of the insulin receptor family, is most abundantly expressed in the kidney. However, its endogenous ligand and physiological roles are still unknown. To elucidate the physiological role of IRR, an orphan receptor, in the kidney, we examined the localization of IRR mRNA and its immunoreactivity in the rat kidney by in situ hybridization and immunohistochemistry, respectively. IRR mRNA was found to be exclusively localized in the cortical collecting duct. The localization of IRR immunoreactivity was consistent with that of IRR mRNA. Furthermore, IRR immunoreactivity was found to be localized on the basolateral plasma membrane of the epithelial cells that were a minor cell subpopulation (20 to 30%) of the duct. The present findings indicated that IRR in the kidney was exclusively localized on the basolateral plasma membrane of type B intercalated cells of the cortical collecting duct.

引用

页码：694 / 698

页数：5

共 50 条

[21] Activity-dependent conformational transitions of the insulin receptor-related receptor
Batishchev, Oleg, V
Kuzmina, Natalia, V
Mozhaev, Andrey A.
Goryashchenko, Alexander S.
Mileshina, Ekaterina D.
Orsa, Alexander N.
Bocharov, Eduard, V
Deyev, Igor E.
Petrenko, Alexander G.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 296
[22] EXPRESSION OF A CDNA-ENCODING THE HUMAN INSULIN RECEPTOR-RELATED RECEPTOR
JUI, HY
SUZUKI, Y
ACCILI, D
TAYLOR, SI
JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (35) : 22446 - 22452
[23] Insulin receptor-related receptor as an extracellular pH sensor regulating bicarbonate excretion
Petrenko, Alexander George
Mozhaev, Andrey
Serova, Oxana
Deyev, Igor
FASEB JOURNAL, 2018, 32 (01):
[24] The insulin receptor-related receptor (Insrr) gene maps to mouse chromosome 3
Tsuji, T
Katoh, H
Kunieda, T
EXPERIMENTAL ANIMALS, 2001, 50 (04) : 359 - 360
[25] Site-Directed Mutagenesis of the Fibronectin Domains in Insulin Receptor-Related Receptor
Deyev, Igor E.
Chachina, Natalia A.
Zhevlenev, Egor S.
Petrenko, Alexander G.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (11):
[26] Insulin Receptor-Related Receptor Regulates the Rate of Early Development in Xenopus laevis
Korotkova, Daria D.
Gantsova, Elena A.
Goryashchenko, Alexander S.
Eroshkin, Fedor M.
Serova, Oxana V.
Sokolov, Alexey S.
Sharko, Fedor
Zhenilo, Svetlana V.
Martynova, Natalia Y.
Petrenko, Alexander G.
Zaraisky, Andrey G.
Deyev, Igor E.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (16)
[27] Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis
Weber, A
Huesken, C
Bergmann, E
Kiess, W
Christiansen, NM
Christiansen, H
CLINICAL CANCER RESEARCH, 2003, 9 (15) : 5683 - 5692
[28] Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins
Xu, P
Jacobs, AR
Taylor, SI
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (21) : 15262 - 15270
[29] Molecular cloning and functional study of rat estrogen receptor-related receptor γ in rat prostatic cells
Lui, Ki
Huang, Yu
Choi, H. L.
Yu, Shan
Wong, K. B.
Chen, Shiuan
Chan, Franky L.
PROSTATE, 2006, 66 (15): : 1600 - 1619
[30] Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor
Liwei Wang
Catherine Hall
Jie Li
Eunhee Choi
Xiao-chen Bai
Nature Structural & Molecular Biology, 2023, 30 : 661 - 669

← 1 2 3 4 5 →