Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity

被引：8

作者：

Woodroffe, P. J. ^{[1
]}

Bridge, L. J. ^{[1
]}

King, J. R. ^{[1
]}

Chen, C. Y. ^{[2
]}

Hill, S. J. ^{[3
]}

机构：

[1] Univ Nottingham, Div Theoret Mech, Ctr Math Med, Sch Math Sci, Nottingham NG7 2RD, England

[2] Natl Univ Kaohsiung, Dept Appl Math, Kaohsiung, Taiwan

[3] Queens Med Ctr, Sch Med, Inst Cell Signalling, Nottingham NG7 2UH, England

来源：

JOURNAL OF MATHEMATICAL BIOLOGY | 2010年 / 60卷 / 03期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

G-protein coupled receptors; Mathematical modelling; Asymptotic analysis; DYNAMICS; DESENSITIZATION; AGONISM;

D O I：

10.1007/s00285-009-0268-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

G-protein coupled receptors (GPCRs) form a crucial component of approximately 80% of hormone pathways. In this paper, the most popular mechanism for activation of GPCRs-the shuttling mechanism-is modelled mathematically. An asymptotic analysis of this model clarifies the dynamics of the system in the absence of drug, in particular which reactions dominate during the different timescales. Equilibrium analysis of the model demonstrates the model's ability to predict constitutive receptor activity.

引用

页码：313 / 346

页数：34

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