Structure and Cytotoxicity of Arnamial and Related Fungal Sesquiterpene Aryl Esters

被引：47

作者：

Misiek, Mathias ^{[3
]}

Williams, Jessica ^{[4
]}

Schmich, Kathrin ^{[3
]}

Huettel, Wolfgang ^{[3
]}

Merfort, Irmgard ^{[3
]}

Salomon, Christine E. ^{[4
]}

Aldrich, Courtney C. ^{[4
]}

Hoffmeister, Dirk ^{[1
,2
]}

机构：

[1] Univ Jena, Dept Pharmaceut Biol, D-07745 Jena, Germany

[2] Univ Jena, Hans Knoll Inst, D-07745 Jena, Germany

[3] Univ Freiburg, D-79104 Freiburg, Germany

[4] Univ Minnesota, Ctr Drug Design, Minneapolis, MN 55455 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 10期

关键词：

SECONDARY MOLD METABOLITES; ARMILLARIA-MELLEA; ANTIBACTERIAL SESQUITERPENOIDS; GENE-CLUSTER; BIOSYNTHESIS; IROFULVEN; SYNTHASE; CANCER;

D O I：

10.1021/np900314p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We report on the structure elucidation of arnamial, a new Delta(2,4)-protoilludane everninate ester from the fungus Armillaria mellea, and on the apoptotic activity of arnamial as well as the cytotoxic activity of structurally related compounds on selected human cancer cells. Arnamial showed cytotoxicity against Jurkat T cells, MCF-7 breast adenocarcinoma, CCRF-CEM lymphoblastic leukemia, and HCT-116 colorectal carcinoma cells at IC50 = 3.9, 15.4, 8.9, and 10.7 mu M, respectively, and the related aryl ester melledonal C showed cytotoxic activity against CCRF-CEM cells (IC50 = 14.75 mu M). [1,2-C-13(2)]Acetate feeding supports a polyketide origin of the orsellinic acid moiety of arnamial.

引用

页码：1888 / 1891

页数：4

共 8 条

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