Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells

被引：20
作者：
Paterson, Alison M. [1 ]
Sharpe, Arlene H. [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
来源：
NATURE IMMUNOLOGY | 2010年 / 11卷 / 02期
关键词：
AUTOIMMUNE-DISEASE; TOLERANCE;
D O I：
10.1038/ni0210-109
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CTLA-4 is a potent coinhibitory molecule that is critical for peripheral T cell tolerance. New data suggest that CTLA-4 exerts its critical immunoregulatory functions by controlling antigen-specific conventional T cells as well as regulatory T cells.
引用
收藏
页码：109 / 111
页数：4
相关论文
共 14 条
  • [1] Bachmann MF, 1999, J IMMUNOL, V163, P1128
  • [2] Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells
    Dejean, Anne S.
    Beisner, Daniel R.
    Ch'en, Irene L.
    Kerdiles, Yann M.
    Babour, Anna
    Arden, Karen C.
    Castrillon, Diego H.
    DePinho, Ronald A.
    Hedrick, Stephen M.
    [J]. NATURE IMMUNOLOGY, 2009, 10 (05) : 504 - 513
  • [3] Modulation of tryptophan catabolism by regulatory T cells
    Fallarino, F
    Grohmann, U
    Hwang, KW
    Orabona, C
    Vacca, C
    Bianchi, R
    Belladonna, ML
    Fioretti, MC
    Alegre, ML
    Puccetti, P
    [J]. NATURE IMMUNOLOGY, 2003, 4 (12) : 1206 - 1212
  • [4] Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
    Fife, Brian T.
    Bluestone, Jeffrey A.
    [J]. IMMUNOLOGICAL REVIEWS, 2008, 224 : 166 - 182
  • [5] CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
    Friedline, Randall H.
    Brown, David S.
    Nguyen, Hai
    Kornfeld, Hardy
    Lee, JinHee
    Zhang, Yi
    Appleby, Mark
    Der, Sandy D.
    Kang, Joonsoo
    Chambers, Cynthia A.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (02) : 421 - 434
  • [6] CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms
    Ise, Wataru
    Kohyama, Masako
    Nutsch, Katherine M.
    Lee, Hyang Mi
    Suri, Anish
    Unanue, Emil R.
    Murphy, Theresa L.
    Murphy, Kenneth M.
    [J]. NATURE IMMUNOLOGY, 2010, 11 (02) : 129 - U45
  • [7] Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
    Lühder, F
    Chambers, C
    Allison, JP
    Benoist, C
    Mathis, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) : 12204 - 12209
  • [8] Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
    Pentcheva-Hoang, Tsvetelina
    Corse, Emily
    Allison, James P.
    [J]. IMMUNOLOGICAL REVIEWS, 2009, 229 : 67 - 87
  • [9] Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
    Perez, VL
    VanParijs, L
    Biuckians, A
    Zheng, XX
    Strom, TB
    Abbas, AK
    [J]. IMMUNITY, 1997, 6 (04) : 411 - 417
  • [10] Reversal of the TCR stop signal by CTLA-4
    Schneider, Helga
    Downey, Jos
    Smith, Andrew
    Zinselmeyer, Bernd H.
    Rush, Catherine
    Brewer, James M.
    Bin Wei
    Hogg, Nancy
    Garside, Paul
    Rudd, Christopher E.
    [J]. SCIENCE, 2006, 313 (5795) : 1972 - 1975
12