Enantioselective Organocatalytic Conjugate Addition of Aldehydes to α,β-Unsaturated Thiol Esters

被引：24
|
作者：
Zhu, Shaolin [1 ]
Wang, You [2 ]
Ma, Dawei [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 16期
基金：
中国国家自然科学基金;
关键词：
asymmetric catalysis; enamine activation; Michael addition; organocatalysis; alpha; beta-unsaturated thiol esters; DIPHENYLPROLINOL SILYL ETHER; ASYMMETRIC MICHAEL REACTIONS; VINYL SULFONES; GAMMA(2)-AMINO ACIDS; 4; STEREOCENTERS; CHIRAL AMINES; WATER; NITROETHYLENE; NITROOLEFINS; NITROALKENES;
D O I：
10.1002/adsc.200900449
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The first example of an organocatalytic asymmetric Michael addition of aldehydes to alpha,beta-unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.
引用
收藏
页码：2563 / 2566
页数：4
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