Tailoring Materials for Modulation of Macrophage Fate

被引：290

作者：

Li, Jinhua ^{[1
,2
]}

Jiang, Xinquan ^{[3
]}

Li, Hongjun ^{[4
,5
,6
,7
]}

Gelinsky, Michael ^{[1
,2
]}

Gu, Zhen ^{[4
,5
,6
,7
]}

机构：

[1] Tech Univ Dresden, Univ Hosp, Ctr Translat Bone Joint & Soft Tissue Res, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Fac Med Carl Gustav Carus, D-01307 Dresden, Germany

[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9,Shanghai Engn Res Ctr Adv, Sch Med,Dept Prosthodont,Shanghai Key Lab Stomato, Coll Stomatol,Shanghai Res Inst Stomatol,Natl Cli, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

[4] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Ctr Minimally Invas Therapeut, Los Angeles, CA 90095 USA

[7] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China

来源：

ADVANCED MATERIALS | 2021年 / 33卷 / 12期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

immunoengineering; immunomodulatory biomaterials; immunotherapy; macrophages; targeted drug delivery; TUMOR-ASSOCIATED MACROPHAGES; TITANIUM SURFACE-TOPOGRAPHY; BIPHASIC CALCIUM-PHOSPHATE; IRON-OXIDE NANOPARTICLES; FOREIGN-BODY REACTION; IN-VIVO; DENDRITIC CELLS; IMMUNE-RESPONSES; DRUG-DELIVERY; NONPROFESSIONAL PHAGOCYTES;

D O I：

10.1002/adma.202004172

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity and adaptive immunity hold great promise for a broad range of prophylactic and therapeutic purposes. This review is focused on the design strategies and principles of immunomodulatory biomaterials from the standpoint of materials science to regulate macrophage fate, such as activation, polarization, adhesion, migration, proliferation, and secretion. It offers a comprehensive survey and discussion on the tunability of material designs regarding physical, chemical, biological, and dynamic cues for modulating macrophage immune response. The range of such tailorable cues encompasses surface properties, surface topography, materials mechanics, materials composition, and materials dynamics. The representative immunoengineering applications selected herein demonstrate how macrophage-immunomodulating biomaterials are being exploited for cancer immunotherapy, infection immunotherapy, tissue regeneration, inflammation resolution, and vaccination. A perspective on the future research directions of immunoregulatory biomaterials is also provided.

引用

页数：38

共 401 条

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