Cancer stem cells: The root of tumor recurrence and metastases

被引：300

作者：

Peitzsch, Claudia ^{[1
,2
,3
,5
,7
]}

Tyutyunnykova, Anna ^{[1
,2
]}

Pantel, Klaus ^{[4
]}

Dubrovska, Anna ^{[1
,2
,5
,6
,7
]}

机构：

[1] Tech Univ Dresden, Fac Med, OncoRay Natl Ctr Radiat Res Oncol, Dresden, Germany

[2] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany

[3] Natl Ctr Tumor Dis NCT, Partner Site Dresden, Dresden, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Dept Tumour Biol, Martinistr 52, D-20246 Hamburg, Germany

[5] German Canc Consortium DKTK, Dresden, Germany

[6] Helmholtz Zentrum Dresden Rossendorf, Inst Radiooncol OncoRay, Dresden, Germany

[7] Deutsch Krebsforschungszentrum DKFZ, Heidelberg, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2017年 / 44卷

关键词：

Cancer stem cells; Circulating tumor cells; Epithelial-mesenchymal transition; Disseminated tumor cells; Metastatic niche; Metastasis-initiating cells; ACUTE MYELOID-LEUKEMIA; EPITHELIAL-MESENCHYMAL TRANSITION; BONE-MARROW; SIDE POPULATION; INTRATUMOR HETEROGENEITY; ALDEHYDE DEHYDROGENASE; CLINICAL-IMPLICATIONS; PROSPECTIVE IDENTIFICATION; OXIDATIVE-PHOSPHORYLATION; PROMOTES RADIORESISTANCE;

D O I：

10.1016/j.semcancer.2017.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis formation can be considered as a culmination of the Darwinian evolutionary process within the tumor, when competition of multiple clones results in the development of cell inherent traits that favor tumor dissemination. Cancer stem cells (CSC) which possess self-renewal properties and genomic instability are considered to be an engine of tumor evolution. Cancer cells which have the capacity to colonize distant organs have the features of CSC and, in addition, exert their tumor-initiating capacity under adverse microenvironmental conditions. Recent studies support an idea that metastases can be driven by the evolved and selected subpopulations of CSC. In this review we discuss the common hallmarks of CSC and metastasis initiating cells (MIC) and prospects for the development of anti-metastatic therapy. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：10 / 24

页数：15

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