A Simple and Fast Method for the Simultaneous Determination of Liquiritigenin and Liquiritin at DNA/Carboxyl MWCNTs Modified GCE

被引：4

作者：

Chen, Jincheng ^{[1
]}

Fu, Bo ^{[1
]}

Liu, Tailin ^{[1
]}

Li, Kang ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China

来源：

JOURNAL OF THE ELECTROCHEMICAL SOCIETY | 2019年 / 166卷 / 14期

基金：

中国国家自然科学基金;

关键词：

ELECTROCHEMICAL OXIDATION; RAT PLASMA; CARBON; ISOLIQUIRITIGENIN; QUANTIFICATION; METHOTREXATE; GROWTH; ACID; DRUG;

D O I：

10.1149/2.1371914jes

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

In this paper, DNA/carboxyl MWCNTs was immobilized on a glassy carbon electrode (GCE) to develop an electrochemical sensor for simultaneous determination of liquiritigenin (LG) and liquiritin (LQ). The adsorptive voltammetric behaviors of LG and LQ at DNA/carboxyl MWCNTs composite film modified GCE were investigated by differential pulse voltammetry (DPV), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The calibration curves for LG and LQ were obtained in the ranges of 0.08-1.60 mu M and 5.0-100.0 mu M with the detection limits of 0.02 and 0.8 mu M (S/N = 3), respectively. The method was applied successfully for the detection of LG and LQ in human blood serum with satisfactory recoveries. It provides a new tool for the research of the pharmacological mechanism of LG and LQ in vivo. (C) 2019 The Electrochemical Society.

引用

页码：H730 / H735

页数：6

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