The mechanisms of activation of normal human serum complement by Escherichia coli strains with K1 surface antigen

被引:6
作者
Bugla-Ploskonska, G. [1 ]
Cisowska, A.
Karpinska, K.
Jankowski, S.
Doroszkiewicz, W.
机构
[1] Univ Wroclaw, Inst Genet & Microbiol, PL-51148 Wroclaw, Poland
[2] Med Univ, Dept Biol & Med Parasitol, PL-50367 Wroclaw, Poland
关键词
D O I
10.1007/BF02931630
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Ten E. coli K1 strains isolated from the urine of children with urinary tract infections were sensitive to the bactericidal action of normal human serum (NHS). The role of the particular mechanisms of complement: activation was determined in the process of killing these strains, showing variable sensitivity to the bactericidal action of NHS; three mechanisms of activation of human complement were observed. Important role of alternative pathway activation in the bactericidal action of NHS against E. coli K1 strains independent of the classical and lectin pathways was not established.
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页码:627 / 632
页数:6
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