Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis

被引：10

作者：

Tanabe, Junya ^{[1
]}

Watanabe, Nobuhide ^{[1
]}

Endo, Akihiro ^{[1
]}

Nagami, Taichi ^{[2
]}

Inagaki, Satoshi ^{[3
]}

Tanabe, Kazuaki ^{[1
]}

机构：

[1] Shimane Univ, Div Cardiol, Fac Med, Matsue, Shimane, Japan

[2] Shimane Univ, Div Urol, Fac Med, Matsue, Shimane, Japan

[3] Shimane Univ, Div Neurol, Fac Med, Matsue, Shimane, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 04期

关键词：

myocarditis; immune checkpoint inhibitor; immune-related adverse event; myasthenia gravis; prednisolone;

D O I：

10.2169/internalmedicine.5412-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report the case of a 75-year-old man with asymptomatic immune checkpoint inhibitor (ICI)-associated myocarditis diagnosed on the basis of elevated levels of creatine kinase (CK), CK-myocardial band and troponin I (TNI). He was suspected of being complicated with myasthenia gravis (MG). High-dose prednisolone (PSL) is associated with a risk of MG exacerbation; therefore, PSL therapy was gradually increased from 5 mg/day to 20 mg/day, which resulted in the normalization of the TNI level, and no PSL-related side effects occurred. MG easily complicates myocarditis as an immune-related adverse event; thus, the treatment plan should be carefully considered.

引用

页码：569 / 573

页数：5

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