Effects of peripheral administration of 5-hydroxytryptamine (5-HT) on 2-deoxy-D-glucose-induced hyperphagia in rats

被引：8
作者：
Sugimoto, Y [1 ]
Yoshikawa, T [1 ]
Yamada, J [1 ]
机构：
[1] Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 10期
关键词：
5-HT; (5-hydroxytryptamine; serotonin); food intake; 2-deoxy-D-glucose; peripheral 5-HT2A receptor; glucoprivation;
D O I：
10.1248/bpb.25.1364
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of peripheral administration of 5-HT (5-hydroxytryptamine, serotonin) on hyperphagia induced by 2-deoxy-(D)-glucose(2-DG) were studied in rats. It was found that 5-HT i.p. reduced 2-DG-elicited feeding in rats dose-dependently. The 5-HT-induced hypophagia was antagonized by the 5-HT2A receptor antagonist, ketanserin. It is known that 2-DG induces glucoprivation, resulting in hyperphagia and hyperglycemia. However, 5-HT did not affect hyperglycemia induced by 2-DG. These results suggest that peripheral injection of 5-HT reduces 2-DG-induced hyperphagia mediated by the peripheral 5-HT2A receptor and that its effects are not due to enhancement of hyperglycemia.
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收藏
页码：1364 / 1366
页数：3
相关论文
共 22 条
[1]   EFFECTS OF DL-FENFLURAMINE AND XYLAMIDINE ON GASTRIC-EMPTYING OF MAINTENANCE DIET IN FREELY FEEDING RATS [J].
BAKER, BJ ;
DUGGAN, JP ;
BARBER, DJ ;
BOOTH, DA .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 150 (1-2) :137-142
[2]   INGESTIVE BEHAVIOR AFTER INTRACEREBRAL AND INTRACEREBROVENTRICULAR INFUSIONS OF GLUCOSE AND 2-DEOXY-D-GLUCOSE [J].
BERTHOUD, HR ;
MOGENSON, GJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1977, 233 (03) :R127-R133
[3]   SEROTONIN AND APPETITE [J].
BLUNDELL, JE .
NEUROPHARMACOLOGY, 1984, 23 :1537-1551
[4]   EFFECTS OF THE 5-HT1C/5-HT2 RECEPTOR AGONISTS DOI AND ALPHA-METHYL-5-HT ON PLASMA-GLUCOSE AND INSULIN LEVELS IN THE RAT [J].
CHAOULOFF, F ;
LAUDE, D ;
BAUDRIE, V .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (03) :435-443
[5]  
Curzon G., 1990, ANN N Y ACAD SCI, V600, P521
[6]   PARA-CHLOROPHENYLALANINE PREVENTS FEEDING INDUCED BY THE SEROTONIN AGONIST "8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO) TETRALIN (8-OH-DPAT) [J].
DOURISH, CT ;
HUTSON, PH ;
CURZON, G .
PSYCHOPHARMACOLOGY, 1986, 89 (04) :467-471
[7]  
Dourish CT, 1995, OBES RES, V3, pS449, DOI 10.1002/j.1550-8528.1995.tb00212.x
[8]   SEROTONIN CONTRACTS THE ISOLATED RAT PYLORUS VIA A 5-HT2-LIKE RECEPTOR [J].
EBERLEWANG, K ;
BRAUN, BT ;
SIMANSKY, KJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (01) :R284-R291
[9]   EFFECTS OF XYLAMIDINE ON PERIPHERAL 5-HYDROXYTRYPTAMINE-INDUCED ANOREXIA [J].
EDWARDS, S ;
STEVENS, RG .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 34 (04) :717-720
[10]   COMPARISONS BETWEEN THE EFFECTS OF 5-HT AND DL-FENFLURAMINE ON FOOD-INTAKE AND GASTRIC-EMPTYING IN THE RAT [J].
FRANCIS, J ;
CRITCHLEY, D ;
DOURISH, CT ;
COOPER, SJ .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 50 (04) :581-585
123