Altered tone-induced Fos expression in the mouse inferior colliculus after early exposure to intense noise

被引：5

作者：

Kai, N ^{[1
]}

Niki, H ^{[1
]}

机构：

[1] RIKEN, BSI, Lab Neurobiol & Emot, Wako, Saitama 3500198, Japan

来源：

NEUROSCIENCE RESEARCH | 2002年 / 44卷 / 03期

关键词：

audiogenic seizure; priming; tone-induced fos expression; inferior colliculus; mice;

D O I：

10.1016/S0168-0102(02)00152-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mice become highly susceptible to audiogenic seizures (AGS) after being exposed to intense, high-frequency noise during a critical period of early life (priming). To determine the critical site for AGS priming in the auditory brainstem, animals in the experimental group were primed at 21 days, and the tone-induced Fos immunoreactivity was examined 1, 7, and 14 days after priming as an index of excitability of neurons. Enhanced Fos immunoreactivity was observed in the inferior colliculus (IC) of the primed mice 7 and 14 days after priming as compared to that of non-primed mice and attenuated Fos expression was observed 1 day after priming. No significant elevation of Fos expression was observed in the cochlear nucleus and the deep layer of the superior colliculus of either type of mice. These results strongly suggest that the IC is the target site of AGS priming. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：305 / 313

页数：9

共 40 条

[1] Toward a molecular definition of long-term memory storage [J].

Bailey, CH ;

Bartsch, D ;

Kandel, ER .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13445-13452

[2] STUDIES IN AUDIOGENIC SEIZURE SUSCEPTIBILITY [J].

BOGGAN, WO ;

FREEDMAN, DX ;

LOVELL, RA ;

SCHLESINGER, K .

PSYCHOPHARMACOLOGIA, 1971, 20 (01) :48-+

[3] FOS-LIKE IMMUNOREACTIVITY IN CENTRAL AUDITORY NEURONS OF THE MOUSE [J].

BROWN, MC ;

LIU, TS .

JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 357 (01) :85-97

[4] Neural activity mapping with inducible transcription factors [J].

Chaudhuri, A .

NEUROREPORT, 1997, 8 (13) :R3-R7

[5] NEURONAL-ACTIVITY AND TONOTOPY IN THE AUDITORY-SYSTEM VISUALIZED BY C-FOS GENE-EXPRESSION [J].

EHRET, G ;

FISCHER, R .

BRAIN RESEARCH, 1991, 567 (02) :350-354

[6] Neurons in the deep layers of superior colliculus play a critical role in the neuronal network for audiogenic seizures: mechanisms for production of wild running behavior [J].

Faingold, CL ;

Randall, ME .

BRAIN RESEARCH, 1999, 815 (02) :250-258

[7] Ethanol and neurotransmitter interactions - From molecular to integrative effects [J].

Faingold, CL ;

N'Gouemo, P ;

Riaz, A .

PROGRESS IN NEUROBIOLOGY, 1998, 55 (05) :509-535

[8] INDUCTION OF AUDIOGENIC-SEIZURES IN NORMAL AND GENETICALLY EPILEPSY-PRONE RATS FOLLOWING FOCAL MICROINJECTION OF AN EXCITANT AMINO-ACID INTO RETICULAR-FORMATION AND AUDITORY NUCLEI [J].

FAINGOLD, CL ;

MILLAN, MH ;

ANDERSON, CAB ;

MELDRUM, BS .

EPILEPSY RESEARCH, 1989, 3 (03) :199-205

[9] C-FOS IMMUNOCYTOCHEMICAL EVIDENCE FOR ACOUSTIC PATHWAY MAPPING IN RATS [J].

FRIAUF, E .

BEHAVIOURAL BRAIN RESEARCH, 1995, 66 (1-2) :217-224

[10] N-methyl-D-aspartate-induced c-Fos expression is enhanced in the forebrain structures related to emotion in Fyn-deficient mice [J].

Hattori, K ;

Yagi, T ;

Maekawa, M ;

Sato, T ;

Yuasa, S .

BRAIN RESEARCH, 2001, 905 (1-2) :188-198

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