PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract

被引：33

作者：

Catanzano, O. ^{[1
]}

d'Ayala, G. Gomez ^{[1
]}

D' Agostino, A. ^{[2
]}

Di Lorenzo, F. ^{[3
]}

Schiraldi, C. ^{[2
]}

Malinconico, M. ^{[1
]}

Lanzetta, R. ^{[3
]}

Bonina, F. ^{[4
]}

Laurienzo, P. ^{[1
]}

机构：

[1] CNR, Inst Polymers Composites & Biomat IPCB, Via Campi Flegrei 34, Naples, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Expt Med, Sch Med, Via L De Crecchio 7, I-80138 Naples, Italy

[3] Univ Naples Federico II, Dept Chem Sci, Complesso Univ Monte S Angelo,Via Cinthia 4, I-80126 Naples, Italy

[4] Univ Catania, Dept Drug Sci, Viale Andrea Doria 6, I-95125 Catania, Italy

来源：

CARBOHYDRATE POLYMERS | 2021年 / 264卷

关键词：

Chitosan; Poly(ethylene glycol); Opuntia ficus-indica; Crosslinking; Wound-healing assay; MOLECULAR-WEIGHT; HYALURONIC-ACID; L; CLADODES; SKIN; DRESSINGS; WOUNDS; POLYSACCHARIDES; STABILITY; SYSTEMS;

D O I：

10.1016/j.carbpol.2021.117987

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In the present study, chitosan-based wound dressings loaded with the extract of Opuntia ficus-indica (OPU) were prepared. OPU is known for its capability to accelerate skin injury repair. Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting. The occurrence of crosslinking reaction was confirmed by FTIR spectroscopy. FTIR and DSC analysis suggested that ionic interactions occur between chitosan and OPU. Tensile tests evidenced that the crosslinking caused a decrease of Young?s modulus, which approaches the value of the human skin modulus. Swelling characteristics, water vapor transmission rate, and release kinetics demonstrated that these films are adequate for the proposed application. Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.

引用

页数：9

共 41 条

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