MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

被引：24

作者：

Stojkovic, Stefan ^{[1
]}

Nossent, Anne Yael ^{[1
]}

Haller, Paul ^{[2
]}

Jaeger, Bernhard ^{[2
,3
]}

Vargas, Kris G. ^{[2
]}

Wojta, Johann ^{[1
,4
,5
]}

Huber, Kurt ^{[2
,3
]}

机构：

[1] Med Univ Vienna, Univ Clin Internal Med 2, Dept Cardiol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

[2] Wilhelminenhospital, Dept Internal Med 3, Cardiol Intens Care Med & Chest Pain Unit, Vienna, Austria

[3] Sigmund Freud Univ, Med Fac, Vienna, Austria

[4] Med Univ Vienna, Core Facil, Vienna, Austria

[5] Ludwig Boltzmann Cluster Cardiovasc Res, Vienna, Austria

来源：

THROMBOSIS AND HAEMOSTASIS | 2019年 / 119卷 / 10期

关键词：

microRNA; platelet function; coronary artery disease; acute myocardial infarction; acute coronary syndrome; CIRCULATING MICRORNAS; MYOCARDIAL-INFARCTION; ENDOTHELIAL-CELLS; PLASMA MICRORNA; EARLY-DIAGNOSIS; EXPRESSION; REACTIVITY; TROPONIN; MIR-223; RISK;

D O I：

10.1055/s-0039-1693702

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Microribonucleic acids (miRs) are small, noncoding ribonucleic acids (RNAs), which play an important role in the regulation of platelet function and activity. Several studies proposed a mechanistic role of platelet-related miRs in the pathophysiology of coronary artery disease (CAD) and atherothrombosis. Circulating, platelet-related miRs have been proposed as diagnostic, prognostic, as well as treatment response biomarkers in CAD and acute coronary syndrome (ACS). In this review, we summarize recent studies on the role of platelet-related miRs in the regulation of platelet function and activity. Furthermore, we review the studies investigating the role of platelet-related miRs as biomarkers in patients with CAD and ACS.

引用

页码：1563 / 1572

页数：10

共 101 条

[1] Measuring microRNAs: Comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods [J].