Matrix Metalloproteinase Inspired Therapeutic Strategies for Bone Diseases

被引：16
作者：
Kou, Longfa [1 ,2 ]
Jiang, Xinyu [1 ,2 ]
Lin, Xinlu [1 ,2 ]
Huang, Huirong [1 ,2 ]
Wang, Jun [1 ,2 ]
Yao, Qing [3 ]
Chen, Ruijie [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharm, Wenzhou, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China
[3] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2021年 / 22卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Matrix metalloproteinase; bone disease; drug delivery; hydrogel; nanomedicine; MMP-responsive; MESENCHYMAL STEM-CELLS; PHOTODYNAMIC MOLECULAR BEACONS; INDUCIBLE GENE H3; INTERVERTEBRAL DISC; IN-VIVO; TISSUE INHIBITOR; DRUG-DELIVERY; MORPHOGENETIC PROTEIN-2; COLLAGEN DEGRADATION; RHEUMATOID-ARTHRITIS;
D O I：
10.2174/1389201021666200630140735
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Matrix Metalloproteinases (MMPs), as a family of zinc-containing enzymes, show the function of decomposing Extracellular Matrix (ECM) and participate in the physiological processes of cell migration, growth, inflammation, and metabolism. Clinical and experimental studies have indicated that MMPs play an essential role in tissue injury and repair as well as tumor diagnosis, metastasis, and prognosis. An increasing number of researchers have paid attention to their functions and mechanisms in bone health and diseases. The present review focuses on MMPs-inspired therapeutic strategies for the treatment of bone-related diseases. We introduce the role of MMPs in bone diseases, highlight the MMPs-inspired therapeutic options, and posit MMPs as a trigger for smart cell/drug delivery.
引用
收藏
页码：451 / 467
页数：17
相关论文
共 142 条
[1]   A MMP7-sensitive photoclickable biomimetic hydrogel for MSC encapsulation towards engineering human cartilage [J].
Aisenbrey, Elizabeth A. ;
Bryant, Stephanie J. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2018, 106 (08) :2344-2355
[2]   ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation [J].
Allen, Jessica L. ;
Cooke, Margaret E. ;
Alliston, Tamara .
MOLECULAR BIOLOGY OF THE CELL, 2012, 23 (18) :3731-3742
[3]   MMP8 polymorphism is associated with susceptibility to osteonecrosis of the femoral head in a Chinese Han population [J].
An, Feimeng ;
Du, Jieli ;
Cao, Yuju ;
Shi, Jianping ;
Guo, Yongchang ;
Jin, Tianbo ;
Li, Jian ;
Chen, Junyu ;
Li, Ping ;
Dong, Mei ;
Wang, Guoqiang ;
Wang, Jianzhong .
ONCOTARGET, 2017, 8 (13) :21561-21566
[4]   Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation [J].
Anjum, Fraz ;
Lienemann, Philipp S. ;
Metzger, Stephanie ;
Biernaskie, Jeff ;
Kallos, Michael S. ;
Ehrbar, Martin .
BIOMATERIALS, 2016, 87 :104-117
[5]   Differences in MMPs and TIMP-1 expression between intervertebral disc and disc herniation [J].
Baillet, Athan ;
Grange, Laurent ;
Trocme, Candice ;
Caudroy, Stephanie ;
Juvin, Robert ;
Birembaut, Philippe ;
Morel, Francoise ;
Gaudin, Philippe .
JOINT BONE SPINE, 2013, 80 (03) :341-342
[6]   Correlation of matrix metalloproteinase (MMP)-1,-2,-3, and-9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease [J].
Basaran, Recep ;
Senol, Mehmet ;
Ozkanli, Seyma ;
Efendioglu, Mustafa ;
Kaner, Tuncay .
JOURNAL OF CLINICAL NEUROSCIENCE, 2017, 41 :46-49
[7]   Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases [J].
Brew, Keith .
FASEB JOURNAL, 2019, 33 (01) :71-87
[8]   Matrix metalloproteinase (MMP)-2 and MMP-9 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice [J].
Bruschi, F. ;
Bianchi, C. ;
Fornaro, M. ;
Naccarato, G. ;
Menicagli, M. ;
Gomez-Morales, M. A. ;
Pozio, E. ;
Pinto, B. .
PARASITE IMMUNOLOGY, 2014, 36 (10) :540-549
[9]   The effects of hydroxyapatite nanoparticles embedded in a MMP-sensitive photoclickable PEG hydrogel on encapsulated MC3T3-E1 pre-osteoblasts [J].
Carles-Carner, Maria ;
Saleh, Leila S. ;
Bryant, Stephanie J. .
BIOMEDICAL MATERIALS, 2018, 13 (04)
[10]   Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts [J].
Catalfamo, Dana L. ;
Calderon, Nadia L. ;
Harden, Scott W. ;
Sorenson, Heather L. ;
Neiva, Kathleen G. ;
Wallet, Shannon M. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2013, 228 (02) :349-361
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