Antiangiogenesis: Current clinical data and future perspectives

被引：33

作者：

Drevs, J ^{[1
]}

Laus, C ^{[1
]}

Medinger, M ^{[1
]}

Schmidt-Gersbach, C ^{[1
]}

Unger, C ^{[1
]}

机构：

[1] Klin Tumorbiol, Freiburg, Germany

来源：

ONKOLOGIE | 2002年 / 25卷 / 06期

关键词：

antiangiogenesis; angiogenic phenotypes; preclinical studies; clinical studies; metronomic therapy;

D O I：

10.1159/000068622

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neovascularization is a prerequisite for progressive growth of solid tumors and their metastases. This process is tightly regulated by a large number of proangiogenic and antiangiogenic factors such as VEGF, bFGF and matrix-metalloproteinases. The inhibition of angiogenesis is an innovative therapeutic approach and could represent a powerful adjunct to traditional therapy of malignant tumors. Preclinical trials have been very successful but in clinical studies meaningful response rates could only be shown in some cases. This might indicate the existence of different angiogenic phenotypes in humans. It seems that at present only a part of the interactions between the angiogenic cytokines are known. In addition, new receptor/ligand systems which regulate the neovascularization are being described. This article presents an overview of the most important angiogenically active substances, preclinical and clinical data, surrogate markers as well as future perspectives.

引用

页码：520 / 527

页数：10

共 53 条

[1]

AHMANN FR, 2001, P ASCO, V20, pB174

[2]

BASSER R, 2001, P AN M AM SOC CLIN, V20, pA100

[3]

Batist G., 2002, P ASCO, V21, pA

[4] Differential effects of thalidomide on angiogenesis and tumor growth in mice [J].

Belo, AV ;

Ferreira, MAND ;

Bosco, AA ;

Machado, RDP ;

Andrade, SP .

INFLAMMATION, 2001, 25 (02) :91-96

[5] Phase I clinical and pharmacokinetic study of oral carboxyamidotriazole, a signal transduction inhibitor [J].

Berlin, J ;

Tutsch, KD ;

Hutson, P ;

Cleary, J ;

Rago, RP ;

Arzoomanian, RZ ;

Alberti, D ;

Feierabend, C ;

Wilding, G .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) :781-789

[6]

BRITTEN C, 2002, P ASCO, V21, pB28

[7] Ongoing trials with matrix metalloproteinase inhibitors [J].

Brown, PD .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2000, 9 (09) :2167-2177

[8] Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer:: antitumor activity and correlation with vascular endothelial growth factor levels [J].

Colleoni, M ;

Rocca, A ;

Sandri, MT ;

Zorzino, L ;

Masci, G ;

Nolè, F ;

Peruzzotti, G ;

Robertson, C ;

Orlando, L ;

Cinieri, S ;

de Braud, F ;

Viale, G ;

Goldhirsch, A .

ANNALS OF ONCOLOGY, 2002, 13 (01) :73-80

[9]

DeMoraes ED, 2001, P AN M AM SOC CLIN, V20, p3a

[10]

Drevs J., 2002, Proceedings of the American Association for Cancer Research Annual Meeting, V43, P1082

← 1 2 3 4 5 6 →