Early-stage gastric MALT lymphomas:: eradication of H-pylori and outcome

被引:0
作者
Palomares, MTDL [1 ]
Ruzo, JS [1 ]
López, JAY [1 ]
García, AA [1 ]
Monreal, FA [1 ]
Vázquez-Iglesias, JL [1 ]
机构
[1] Gastrointestinal Tract Dept, La Coruna, Spain
关键词
lymphoma; mucosa-associated lymphoid tissue; low-grade; endosonography; Helicobacter pylori;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Backgrounds and objective: lymphomas of mucosa-associated lymphoid tissue are special because of their indolent course. Low-grade early-stage tumors resolve after Helicobacter pylori (HP) eradication in a high percentage of cases. The aim of this study was to evaluate this regression in our patients with El, stage-low-grade B gastric lymphomas after eradication therapy since the introduction of echoendoscopic examinations in the Gastroenterology Department of 'Juan Canalejo' Hospital. Material and methods: a retrospective study of all cases of low-grade MALT gastric lymphomas in El, stage, diagnosed by histological and echoendoscopic examination, from June 1997 to December 2001. After eradication of HP with triple therapy, patients have been followed-up with endoscopic examinations at 2, 3 and 6 months, and yearly afterwards. Results: there were 14 patients in this period with low-grade EI1 stage gastric MALT B cell lymphoma. The median age was 65 years, and 57% were females. HP was eradicated in all cases with first-or second-line (2 patients) antibiotic treatment. Complete remission was observed in 10 patients (71.4%) in a median time of 4.5 months. The other 4 patients needed chemotherapy because of non-remission or early relapse, and also as initial treatment. Complete remission was also obtained in these patients. Only 9 patients have been followed up in our unit for a median time of 20 months, period after which all remain free of disease. Conclusions: low-grade early-stage MALT gastric B-cell lymphomas have a high rate of response to HP eradication therapy. Echoendoscopic staging helps in distinguishing the group of patients who will benefit from conservative treatment. These patients must be followed up as it remains unclear whether remission is maintained in the long term, and to know what factors could be associated with lymphoma relapse.
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页码:674 / 678
页数:5
相关论文
共 21 条
  • [1] Molecular diagnostics in low-grade gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type after Helicobacter pylori eradication therapy
    Alpen, B
    Thiede, C
    Wündisch, T
    Bayerdörffer, E
    Stolte, M
    Neubauer, A
    [J]. CLINICAL LYMPHOMA, 2001, 2 (02): : 103 - 108
  • [2] Bonis RT, 1999, REV ESP ENFERM DIG, V91, P520
  • [3] ENNO A, 1995, AM J PATHOL, V147, P217
  • [4] Primary gastric B-cell lymphoma:: Results of a prospective multicenter study
    Fischbach, W
    Dragosics, B
    Kolve-Goebeler, ME
    Ohmann, C
    Greiner, A
    Yang, Q
    Böhm, S
    Verreet, P
    Horstmann, O
    Busch, M
    Dühmke, E
    Müller-Hermelink, HK
    Wilms, K
    [J]. GASTROENTEROLOGY, 2000, 119 (05) : 1191 - 1202
  • [5] Gisbert JP, 1998, MED CLIN-BARCELONA, V110, P56
  • [6] MALIGNANT-LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE
    ISAACSON, PG
    SPENCER, J
    [J]. HISTOPATHOLOGY, 1987, 11 (05) : 445 - 462
  • [7] Jover GF, 1999, REV ESP ENFERM DIG, V91, P545
  • [8] Montalban C, 2001, HAEMATOLOGICA, V86, P609
  • [9] Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of Helicobacter pylori
    Nakamura, S
    Matsumoto, T
    Suekane, H
    Takeshita, M
    Hizawa, K
    Kawasaki, M
    Yao, T
    Tsuneyoshi, M
    Iida, M
    Fujishima, M
    [J]. GUT, 2001, 48 (04) : 454 - 460
  • [10] Nobre-Leitao C, 1998, AM J GASTROENTEROL, V93, P732, DOI 10.1111/j.1572-0241.1998.215_a.x