COX-2 inhibitors celecoxib and parecoxib: Valuable options for postoperative pain management

被引：20
作者：
Gajraj, Noor M. [1 ]
机构：
[1] Baylor Univ, Med Ctr, Baylor Ctr Pain Management, Frisco, TX 75034 USA
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 03期
关键词：
celecoxib; parecoxib; postoperative pain;
D O I：
10.2174/156802607779941323
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
COX-2 inhibitors are equally as efficacious as the non-selective NSAIDs for the treatment of postoperative pain, but have the advantages of a better gastrointestinal side-effect profile as well as a lack of antiplatelet effects. There have been recent concerns regarding the cardiovascular side effects of COX-2 inhibitors. Nonetheless, they remain a valuable option for postoperative pain management. The pharmacology of these agents and available studies are reviewed.
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收藏
页码：235 / 249
页数：15
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