Synthesis of Selectively Mono-N-Arylated Aliphatic Diamines via Iridium-Catalyzed Amine Alkylation

被引：105
|
作者：
Blank, Benoit [1 ]
Michlik, Stefan [1 ]
Kempe, Rhett [1 ]
机构：
[1] Univ Bayreuth, Lehrstuhl Anorgan Chem 2, D-95440 Bayreuth, Germany
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 17期
关键词：
amine alkylation; amino alcohols; diamines; iridium; ASTERISK-IR COMPLEX; BORROWING HYDROGEN; REDUCTIVE AMINATION; TERTIARY-AMINES; ALCOHOLS; SECONDARY; HYDROAMINATION; HETEROCYCLIZATION; ACTIVATION; COORDINATION;
D O I：
10.1002/adsc.200900548
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A highly selective phosphorus/nitrogen (P,N) ligand-based iridium catalyst system efficiently catalyzes the reaction of arylamines with unprotected amino alcohols, yielding N-arylated aliphatic diamines in yields of up to 93%. The reaction can be performed with a wide variety of branched and linear amino alcohols in combination with various aminopyridines or substituted anilines.
引用
收藏
页码：2903 / 2911
页数：9
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