Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil

被引：30
作者：
de Medeiros, Luzidalva Barbosa
Lacerda, Heloisa Ramos
Salustiano Cavalcanti, Ana Maria
Pessoa Militao de Albuquerque, Maria de Fatima
机构：
[1] Univ Fed Pernambuco, Hosp Clin Pos Grad Med Trop, BR-50670420 Recife, PE, Brazil
[2] Univ Fed Pernambuco, Dept Clin Med, BR-50670420 Recife, PE, Brazil
[3] Secretaria Estadual Saude Pernambuco, Cent Lab, Recife, PE, Brazil
来源：
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2006年 / 101卷 / 08期
关键词：
human imunodeficiency virus type 1; primary resistance to drugs; genotyping; subtypes; Brazil;
D O I：
10.1590/S0074-02762006000800004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied Genotyping was performed using the ViroSeq (TM) Geno yping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%) Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.
引用
收藏
页码：845 / 849
页数：5
相关论文
共 36 条
  • [1] Persistence of primary drug resistance among recently HIV-1 infected adults
    Barbour, JD
    Hecht, FA
    Wrin, T
    Liegler, TJ
    Ramstead, CA
    Busch, MP
    Segal, MR
    Petropoulos, CJ
    Grant, RM
    [J]. AIDS, 2004, 18 (12) : 1683 - 1689
  • [2] Barreto CC, 2006, JAIDS-J ACQ IMM DEF, V41, P338
  • [3] HIV-1 drug resistance in newly infected individuals
    Boden, D
    Hurley, A
    Zhang, LQ
    Cao, YZ
    Guo, Y
    Jones, E
    Tsay, J
    Ip, J
    Farthing, C
    Limoli, K
    Parkin, N
    Markowitz, M
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (12): : 1135 - 1141
  • [4] Persistence of multidrug-resistant HIV-1 in primary infection leading to superinfection (vol 18, pg 1653, 1660)
    Brenner, B
    Routy, JP
    Quan, YD
    Moisi, D
    Oliveira, M
    Turner, D
    Wainberg, MA
    [J]. AIDS, 2004, 18 (15) : 2107 - 2107
  • [5] Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection
    Brenner, BG
    Routy, JP
    Petrella, M
    Moisi, D
    Oliveira, M
    Detorio, M
    Spira, B
    Essabag, V
    Conway, B
    Lalonde, R
    Sekaly, RP
    Wainberg, MA
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (04) : 1753 - 1761
  • [6] Sequence diversity of the reverse transcriptase of human immunodeficiency virus type 1 from untreated Brazilian individuals
    Brindeiro, R
    Vanderborght, B
    Caride, E
    Correa, L
    Oravec, RM
    Berro, O
    Stuyver, L
    Tanuri, A
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (07) : 1674 - 1680
  • [7] Brazilian Network for HIV Drug Resistance Surveillance (HIV-BResNet): a survey of chronically infected individuals
    Brindeiro, RM
    Diaz, RS
    Sabino, EC
    Morgado, MG
    Pires, IL
    Brigido, L
    Dantas, MC
    Barreira, D
    Teixeira, PR
    Tanuri, A
    [J]. AIDS, 2003, 17 (07) : 1063 - 1069
  • [8] CASEIRO MM, 2001, THESIS U FEDERAL SAO
  • [9] Clavel F, 2004, NEW ENGL J MED, V350, P1023, DOI 10.1056/NEJM2ra025195
  • [10] D'Aquila Richard T., 2002, Top HIV Med, V10, P21
1234