Proposals for standardized Protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes

被引:64
作者
Haferlach, Claudia
Rieder, Harald
Lillington, Debra M.
Dastugue, Nicole
Hagemeijer, Anne
Harbott, Jochen
Stilgenbauer, Stephan
Knuutila, Sakari
Johansson, Bertil
Fonatsch, Christa
机构
[1] Munich Leukemia Lab, D-81377 Munich, Germany
[2] Univ Dusseldorf, Inst Humangenet & Anthropol, Dusseldorf, Germany
[3] Queen Mary Coll, Canc Res UK, Med Oncol Lab, Barts & Royal London Sch Med & Dent, London, England
[4] Hop Purpan, Hematol Lab, Toulouse, France
[5] Katholieke Univ Leuven, Ctr Human Genet, Louvain, Belgium
[6] Univ Giessen, Childrens Hosp, Dept Pediat Hematol & Oncol, Giessen, Germany
[7] Univ Ulm, Dept Internal Med 3, D-7900 Ulm, Germany
[8] Univ Helsinki, Haartman Inst, Dept Pathol, Helsinki, Finland
[9] Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden
[10] Med Univ Vienna, Dept Humangenet, Clin Inst Med & Chem Lab Diagnost, Vienna, Austria
关键词
D O I
10.1002/gcc.20433
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The impact of cytogenetic characterization based on chromosome banding analyses and fluorescence in situ hybridization on clinical decision making has increased dramatically during recent years. Therefore, laboratory techniques have to be optimized to provide reliable results for optimal patient care. In addition, quick and correct results save time and money by preventing unnecessary additional diagnostics and suboptimal treatment approaches. It was our aim to present proposals for standardized protocols to improve the diagnosis, and hence the treatment outcome, of hematologic malignancies. (c) 2007 Wiley-Liss, Inc.
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收藏
页码:494 / 499
页数:6
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