The preparation of metal-organic frameworks and their biomedical application

被引：90

作者：

Liu, Rong ^{[1
,2
]}

Yu, Tian ^{[1
]}

Shi, Zheng ^{[1
]}

Wang, Zhiyong ^{[3
]}

机构：

[1] Chengdu Univ, Sch Med & Nursing, Chengdu 610106, Peoples R China

[2] Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610106, Peoples R China

[3] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Paul C Lauterbur Res Ctr Biomed Imaging,Shenzhen, Shenzhen 518055, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2016年 / 11卷

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

metal-organic frameworks; pore creation; the controlled size; biocompatibility; drug releasing performances; imaging; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY; COORDINATION POLYMERS; MICROPOROUS METAL; HYDROGEN STORAGE; PARTICLE-SIZE; NANOPARTICLES; DESIGN; RELEASE; ACID;

D O I：

10.2147/IJN.S100877

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The development of a safe and targetable drug carrier is a major challenge. An efficient delivery system should protect cargo from degradation and cleanup, and control of drug release in the target site. Metal-organic frameworks (MOFs), consisting of metal ions and a variety of organic ligands, have been applied for drug delivery due to their distinct structure. In this review, we summarized the synthesis strategies of MOFs, especially emphasizing the methods of pore creation in frameworks, which were based on recent literatures. Subsequently, the controlled size, biocompatibility, drug releasing performances, and imaging of MOFs were discussed, which would pave the road for the application in drug-delivery systems.

引用

页码：1187 / 1200

页数：14

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