Multiple physiological functions for multidrug transporter P-glycoprotein?

被引:292
作者
Johnstone, RW [1 ]
Ruefli, AA [1 ]
Smyth, MJ [1 ]
机构
[1] Austin Hosp, Austin Res Inst, Cellular Cytotox Lab, Heidelberg, Vic 3084, Australia
关键词
D O I
10.1016/S0968-0004(99)01493-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.
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收藏
页码:1 / 6
页数:8
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