Characterization of glycopeptide-resistant Enterococcus faecium (GRE) from broilers and pigs in Denmark:: Genetic evidence that persistence of GRE in pig herds is associated with coselection by resistance to macrolides

被引:144
作者
Aarestrup, FM [1 ]
机构
[1] Danish Vet Lab, DK-1790 Copenhagen, Denmark
关键词
D O I
10.1128/JCM.38.7.2774-2777.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Glycopeptide-resistant enterococci (GRE) from broilers and pigs were characterized to investigate the background for the persistence of GRE in pig herds. All porcine isolates belonged to closely related pulsed-field gel electrophoretic (PFGE) types, with the ermB and vanA genes located on the same transferable genetic element. Broiler isolates belonged to different PFGE types. The persistence of GRE in Danish pig herds after the ban of glycopeptides may be explained by the genetic link between ermB and vanA and coselection by use of macrolides for treatment and growth promotion.
引用
收藏
页码:2774 / 2777
页数:4
相关论文
共 31 条
[1]   Resistance to antimicrobial agents used for animal therapy in pathogenic-, zoonotic- and indicator bacteria isolated from different food animals in Denmark: a baseline study for the Danish Integrated Antimicrobial Resistance Monitoring Programme (DANMAP) [J].
Aarestrup, FM ;
Bager, F ;
Jensen, NE ;
Madsen, M ;
Meyling, A ;
Wegener, HC .
APMIS, 1998, 106 (08) :745-770
[2]   Occurrence of glycopeptide resistance among Enterococcus faecium isolates from conventional and ecological poultry farms [J].
Aarestrup, FM .
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 1995, 1 (03) :255-257
[3]   Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the vanA cluster [J].
Aarestrup, FM ;
Ahrens, P ;
Madsen, M ;
Pallesen, LV ;
Poulsen, RL ;
Westh, H .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (08) :1938-1940
[4]  
AARESTRUP FM, IN PRESS DIAGN MICRO
[5]   Glycopeptide resistance in Enterococcus faecium from broilers and pigs following discontinued use of avoparcin [J].
Bager, F ;
Aarestrup, FM ;
Madsen, M ;
Wegener, HC .
MICROBIAL DRUG RESISTANCE, 1999, 5 (01) :53-56
[6]   Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faecium on Danish poultry and pig farms [J].
Bager, F ;
Madsen, M ;
Christensen, J ;
Aarestrup, FM .
PREVENTIVE VETERINARY MEDICINE, 1997, 31 (1-2) :95-112
[7]   A GENERAL-METHOD FOR DETECTING AND SIZING LARGE PLASMIDS [J].
BARTON, BM ;
HARDING, GP ;
ZUCCARELLI, AJ .
ANALYTICAL BIOCHEMISTRY, 1995, 226 (02) :235-240
[8]   FARM-ANIMALS AS A PUTATIVE RESERVOIR FOR VANCOMYCIN-RESISTANT ENTEROCOCCAL INFECTION IN MAN [J].
BATES, J ;
JORDENS, JZ ;
GRIFFITHS, DT .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (04) :507-514
[9]   Plasmid-mediated coresistance to streptogramins and vancomycin in Enterococcus faecium HM1032 [J].
Bozdogan, B ;
Leclercq, R ;
Lozniewski, A ;
Weber, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (08) :2097-2098
[10]   Characterization of the vanD glycopeptide resistance gene cluster from Entercoccus faecium BM4339 [J].
Casadewall, B ;
Courvalin, P .
JOURNAL OF BACTERIOLOGY, 1999, 181 (12) :3644-3648