The gut-brain axis in irritable bowel syndrome and inflammatory bowel disease

被引：50

作者：

Ancona, Angela ^{[1
]}

Petito, Claudia ^{[2
]}

Iavarone, Irene ^{[1
]}

Petito, Valentina ^{[3
]}

Galasso, Linda ^{[1
]}

Leonetti, Alessia ^{[1
]}

Turchini, Laura ^{[1
]}

Belella, Daniela ^{[2
]}

Ferrarrese, Daniele ^{[2
]}

Addolorato, Giovanni ^{[1
,3
]}

Armuzzi, Alessandro ^{[1
,3
]}

Gasbarrini, Antonio ^{[1
,3
]}

Scaldaferri, Franco ^{[1
,3
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Med & Chirurg, I-00168 Rome, Italy

[2] Fdn Policlin Univ A Gemelli IRCCS, Unita Operat Semplice Psicol Clin Osped, I-00168 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Med & Chirurg Traslaz, I-00168 Rome, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2021年 / 53卷 / 03期

关键词：

Gut-brain axis; Gut inflammation; IBD; IBS; Probiotics; Psychobiotics;

D O I：

10.1016/j.dld.2020.11.026

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Research increasingly demonstrates the bidirectional communication between gut microbiota and the brain, enhancing the role of gut microbiota modulation in the treatment of central nervous system (CNS) disorders. The first five years of life are extremely important as it affects the development of gut microbiota, immune system and, consequently, the onset of psychometric alterations, particularly in genetically predisposed individuals. In this review, we focus on the link between specific microbial genera, gastrointestinal (GI) disorders, anxiety and depression and on the effects of different therapeutic strategies for mood disorders on gut microbiota. (C) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：298 / 305

页数：8

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