Circulating metabolites are associated with brain atrophy and white matter hyperintensities

被引：15

作者：

de Leeuw, Francisca A. ^{[1
]}

Karamujic-Comic, Hata ^{[2
]}

Tijms, Betty M. ^{[1
]}

Peeters, Carel F. W. ^{[3
]}

Kester, Maartje I. ^{[4
]}

Scheltens, Philip ^{[1
]}

Ahmad, Shahzad ^{[2
]}

Vojinovic, Dina ^{[2
]}

Adams, Hieab H. H. ^{[5
,6
]}

Hankemeier, Thomas ^{[2
,7
,8
]}

Bos, Daniel ^{[2
,5
]}

van der Lugt, Aad ^{[5
]}

Vernooij, Meike W. ^{[2
,5
]}

Ikram, M. Arfan ^{[2
]}

Amin, Najaf ^{[2
]}

Barkhof, Frederik ^{[9
,10
,11
]}

Teunissen, Charlotte E. ^{[12
]}

van Duijn, Cornelia M. ^{[2
,13
,14
]}

van der Flier, Wiesje M. ^{[1
,3
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol, Doctor Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands

[3] Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[4] Flevoziekenhuis, Dept Neurol, Almere, Netherlands

[5] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[6] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

[7] Leiden Univ, Leiden Acad Ctr Drug Res, Fac Sci, Div Analyt Biosci, Leiden, Netherlands

[8] Leiden Univ, Translat Epidemiol, Fac Sci, Leiden, Netherlands

[9] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[10] UCL London, Inst Neurol, London, England

[11] UCL London, Inst Healthcare Engn, London, England

[12] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Neurochem Lab,Dept Clin Chem, Amsterdam, Netherlands

[13] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

[14] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England

来源：

ALZHEIMERS & DEMENTIA | 2021年 / 17卷 / 02期

基金：

荷兰研究理事会; 欧盟地平线“2020”;

关键词：

Alzheimer's disease; cholesterol; glucose; lipids; magnetic resonance imaging (MRI); metabolism;

D O I：

10.1002/alz.12180

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

引用

页码：205 / 214

页数：10

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