A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

被引：365

作者：

Gudbjartsson, Daniel F. ^{[1
]}

Holm, Hilma ^{[1
,2
]}

Gretarsdottir, Solveig ^{[1
]}

Thorleifsson, Gudmar ^{[1
,3
,4
]}

Walters, G. Bragi ^{[1
]}

Thorgeirsson, Gudmundur

Gulcher, Jeffrey ^{[1
]}

Mathiesen, Ellisiv B. ^{[5
,6
]}

Njolstad, Inger ^{[7
]}

Nyrnes, Audhild ^{[7
,8
]}

Wilsgaard, Tom ^{[7
]}

Hald, Erin M. ^{[9
]}

Hveem, Kristian ^{[10
]}

Stoltenberg, Camilla ^{[11
]}

Kucera, Gayle ^{[12
]}

Stubblefield, Tanya ^{[12
]}

Carter, Shannon ^{[12
]}

Roden, Dan ^{[12
]}

Ng, Maggie C. Y. ^{[13
]}

Baum, Larry ^{[13
]}

So, Wing Yee ^{[13
]}

Wong, Ka Sing ^{[13
]}

Chan, Juliana C. N. ^{[13
]}

Gieger, Christian ^{[14
]}

Wichmann, H-Erich ^{[14
]}

Gschwendtner, Andreas ^{[15
]}

Dichgans, Martin ^{[15
]}

Kuhlenbaeumer, Gregor ^{[16
]}

Berger, Klaus ^{[17
]}

Ringelstein, E. Bernd ^{[18
,19
]}

Bevan, Steve ^{[20
]}

Markus, Hugh S. ^{[20
]}

Kostulas, Konstantinos ^{[21
]}

Hillert, Jan ^{[21
]}

Sveinbjornsdottir, Sigurlaug ^{[22
]}

Valdimarsson, Einar M. ^{[22
]}

Lochen, Maja-Lisa ^{[7
,9
]}

Ma, Ronald C. W. ^{[13
]}

Darbar, Dawood ^{[12
]}

Kong, Augustine ^{[1
]}

Arnar, David O. ^{[3
,4
]}

Thorsteinsdottir, Unnur ^{[1
,4
]}

Stefansson, Kari ^{[1
,4
]}

机构：

[1] DeCode Genet, Reykjavik, Iceland

[2] Emory Univ, Sch Med, Div Cardiol, Dept Internal Med, Atlanta, GA 30322 USA

[3] Landspitali Univ Hosp, Div Cardiol, Dept Internal Med, Reykjavik, Iceland

[4] Univ Iceland, Fac Med, Reykjavik, Iceland

[5] Univ Tromso, Inst Clin Med, Tromso, Norway

[6] Univ Hosp N Norway, Dept Neurol, Tromso, Norway

[7] Univ Tromso, Inst Community Med, Tromso, Norway

[8] Univ Hosp N Norway, Dept Geriatr, Tromso, Norway

[9] Univ Hosp N Norway, Dept Cardiol, Tromso, Norway

[10] Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7034 Trondheim, Norway

[11] Norwegian Inst Publ Hlth, Oslo, Norway

[12] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

[13] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[14] German Res Ctr Environm Hlth, Helmholtz Zentrum Munich, Inst Epidemiol, Neuherberg, Germany

[15] Univ Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany

[16] Univ Kiel, Inst Expt Med, Kiel, Germany

[17] Inst Epidemiol & Social Med, Munster, Germany

[18] Univ Munster, Dept Neurol, Munster, Germany

[19] Univ Munster, Leibniz Inst Atherosclerosis Res, Munster, Germany

[20] St Georges Univ London, London, England

[21] Karolinska Univ Hosp Huddinge, Dept Neurol, Stockholm, Sweden

[22] Landspitali Univ Hosp, Dept Neurol, Reykjavik, Iceland

来源：

NATURE GENETICS | 2009年 / 41卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CHROMOSOME; 4Q25; ATBF1; RISK; METAANALYSIS; PROTEIN;

D O I：

10.1038/ng.417

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.

引用

页码：876 / 878

页数：3

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