Algal transformation of hydrocortisone by the cyanobacterium Nostoc ellipsosporum

被引：8
|
作者：
Ghasemi, Y.
Yazdi, M. Tabatabaei
Dehshahri, A.
Niknahad, H.
Shokravi, S.
Amini, M.
Ghasemian, A.
Faramarzi, M. A.
机构：
[1] Shiraz Univ Med Sci, Dept Pharmacognosy, Tehran, Iran
[2] Shiraz Univ Med Sci, Dept Pharmaceut Biotechnol, Tehran, Iran
[3] Shiraz Univ Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Tehran, Iran
[4] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran
[5] Shaheed Beheshti Univ Med Sci, Dept Biol, Inst Appl Sci, Iranian Ctr Culture & Educ, Tehran, Iran
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2006年 / 42卷 / 06期
关键词：
biotransformation; hydrocortisone; microalgae; Nostoc ellipsosporum;
D O I：
10.1007/s10600-006-0257-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The potential of Nostoc ellipsosporum for biotransformation of hydrocortisone was studied. The microorganism was isolated during a screening program from soil samples collected from the paddy fields in the north of Iran and had not been previously examined for this purpose. The biotransformation yielded 11 beta,17 alpha,20 beta, 21-tetrahydroxypregn-4-en-3-one and 11 beta-hydroxyandrost-4-ene-3,17-dione. Both of the metabolites were purified chromatographically and characterized using instrumental analyses.
引用
收藏
页码：702 / 705
页数：4
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